Evidence mapPaperPMID 41853274Full record

ArticleFrontiers in immunology2026

Ana Fadhel Alvarez, Zheng Yin, Beanna Okeugo, Alexander Banerjee, Meng Luo, Christopher M Taylor, Salomea Giorgberidze, Vaishali Harne, Rambabu Majji, Melissa N Munroe and 7 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ana Fadhel Alvarez *Division of Gastroenterology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Zheng Yin *Systems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX, United States.
Beanna OkeugoDivision of Gastroenterology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Alexander BanerjeeDepartment of Pathology and Laboratory Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Meng LuoMicrobial Genomics Resource Group, Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Christopher M TaylorMicrobial Genomics Resource Group, Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Salomea GiorgberidzeDivision of Gastroenterology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Vaishali HarneDivision of Gastroenterology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Rambabu MajjiJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.
Melissa N MunroeDivision of Gastroenterology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Ji Ho SuhDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Stephen T C WongSystems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX, United States.
Kang Ho KimDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Hari Krishna YalamanchiliJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.
Suhair Al SalihiDepartment of Pathology and Laboratory Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Jon Marc RhoadsDivision of Gastroenterology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, TX, United States.
Yuying LiuDivision of Gastroenterology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, TX, United States.

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · BAYLOR COLLEGE OF MEDICINE · 2001 to 2025
$5.7M
THE ROLE OF HEPATOKINE ORM2 IN ADIPOSE TISSUE INFLAMMATIONR01DK126656 · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2025 to 2025
$390k
NIAID NIH HHS R03 AI153725NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK126656
6 · The paper itself

Abstract

Background: A deficiency of immunosuppressive regulatory T cells, as seen in scurfy (SF) mice or in IPEX syndrome in humans, can lead to multiorgan inflammation. Oral administration of the probiotic Methods: To characterize CD4 Results: Prob-SF-CD4 Conclusions: Inflammatory lymphocytes (CD4

Indexed as

CD4-Positive T-LymphocytesImmunocompromised HostLimosilactobacillus reuteriLiverProbioticsTranscriptomeAnimalsDisease Models, AnimalInflammationMiceMice, Inbred C57BLMice, Knockoutautoimmunitygut microbiotahepatic transcriptomeinflammationprobiotic-modulated T cellprobioticsRAG1 knockout miceTreg deficiency

Identifiers

PMID41853274
PMCPMC12992261

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.