ArticleCureus2026
Clinical Characteristics and Long-Term Outcomes of Young Women With Breast Cancer: A Multicenter Study From Uruguay.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer in women aged ≤40 years is uncommon but clinically challenging, often associated with aggressive pathological features and advanced-stage diagnosis. In Latin America, real-world data on long-term outcomes in this population remain limited. This study aimed to describe clinicopathological characteristics, treatment patterns, and survival outcomes of young women with breast cancer treated in Uruguay.
methodsWe conducted a multicenter retrospective cohort study including women aged 18-40 years diagnosed with invasive breast cancer between 2006 and 2024 at two public referral centers. Clinical, pathological, and treatment data were collected from medical records. Overall survival (OS) and disease-free survival (DFS) were estimated using Kaplan-Meier analysis.
resultsA total of 267 patients were included (mean age at diagnosis, 34.8 years). Invasive ductal carcinoma was the predominant histology (85.8%), with a high proportion of grade III tumors (39.3%). The most common biological subtype was luminal (48.8%), followed by HER2-positive (27.7%) and triple-negative disease (17.2%). Stage II disease was most frequent (40.4%), while 28.7% of patients presented with stage III disease. Modified radical mastectomy was the most commonly performed surgical procedure (38.2%). Most patients received surgery, radiotherapy, and systemic therapy according to recurrence risk. With a median follow-up of 52.3 months, estimated OS was 84.8% at 5 years and 80.9% at 10 years. Survival outcomes differed significantly according to clinical stage but not biological subtype.
conclusionsYoung women with breast cancer in Uruguay frequently present with aggressive tumor features and advanced disease at diagnosis. Nevertheless, when managed within a multidisciplinary framework and treated according to current standards of care, long-term survival outcomes are favorable and comparable to international reports. These findings underscore the importance of early detection strategies and equitable access to guideline-based care in middle-income countries.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.