ArticleThe journal of physical chemistry letters2026
Amyloid-β "Co-assembles" with Coatomer Subunit Delta (δ-COP).
Article in The journal of physical chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Previous studies showed that δ-COP interacts with APP and regulates its intracellular trafficking, while an important reduction in the level of Aβ plaques was observed in AD/δ-COP I422T mice. Here, we show that δ-COP interacts directly with Aβ assemblies according to experiments and simulations. Experiments suggest a two-binding site model, one with high affinity and one with lower affinity. Simulations comply with experiments and provide mechanistic biophysical insights into the high-affinity interactions, comprising a "co-assembly-like" β-sheet interaction within nearly identical domains
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