Trial reportExperimental physiology2026
Exercise-induced miR-126 expression improves vascular health in prediabetes: A randomized controlled trial.
Trial report in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exercise-induced miR-126 expression improves vascular health in prediabetes: A randomized controlled trial.Experimental physiology · 2026Trial
- Experimental Physiology Special Issue: Exercise as Medicine.Experimental physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
In this study, we investigated whether a structured aerobic exercise programme could enhance microRNA-126 (miR-126) expression and improve subclinical atherosclerosis markers [carotid intima-media thickness (CIMT) and ankle-brachial index (ABI)] in individuals with prediabetes. In this 12 week, multicentre, assessor-blinded, randomized controlled trial, 64 adults aged 18-60 years with newly diagnosed prediabetes were randomized into exercise and control groups. The exercise group performed supervised moderate-intensity aerobic exercise programme three times per week (treadmill and cycling, 50%-70% of maximum heart rate), and both groups received standard lifestyle advice. Circulating miR-126 expression was assessed via ΔCt using qPCR at baseline and week 12. The mean age was 46.82 ± 7.94 years, and 75.0% were female. Within- and between-group comparisons of ΔCt miR-126 were evaluated using a two-way repeated-measures ANOVA, demonstrating a significant main effect of time (P < 0.001) and a significant group × time interaction (P = 0.007). A significant group × time interaction was observed for both ABI and CIMT, with the exercise group showing an increase in ABI and a reduction in CIMT compared with the control group (ABI, P = 0.017; CIMT, P = 0.007). Correlation analysis revealed a positive association between change in ΔCt and CIMT (r = 0.260, P = 0.045) and a negative correlation with ABI (r = -0.275, P = 0.034). A 12 week aerobic exercise intervention significantly increased miR-126 expression and was associated with improvements in vascular markers of subclinical atherosclerosis, as evidenced by reduced CIMT and increased ABI. These vascular changes might be influenced, in part, by miR-126-related endothelial pathways among multiple mechanisms, highlighting the potential of miR-126 as a biomarker and therapeutic target for early vascular protection in prediabetes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.