Evidence map›Paper›PMID 41854751›Full record

ReviewApoptosis : an international journal on programmed cell death2026

The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.

Kai Nan, Lei Zhang, Yan Zhao, Su Yin, Yulong Peng, Jing Huang, Lin Liu, Zhaohui Yi, Hongchao Yu, Zhi Yang

Abstract readReview
In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai NanDepartment of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 666, Jianyuan 2nd Road, Xi'an, 710054, Shaanxi Province, People's Republic of China.
Lei ZhangDepartment of Pharmacy, Shaanxi Provincial Hospital of Chinese Medicine, No. 23, Hanguang Road, Xi'an, 710003, Shaanxi, People's Republic of China.
Yan ZhaoCentre of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157 Xiwu Road, Xi'an, 710004, Shaanxi, People's Republic of China.
Su YinThe Affiliated Hospital of Shaanxi University of Chinese Medicine, No.2 Weiyang Road, Xianyang, 712046, Shaanxi, People's Republic of China.
Yulong PengThe Affiliated Hospital of Shaanxi University of Chinese Medicine, No.2 Weiyang Road, Xianyang, 712046, Shaanxi, People's Republic of China.
Jing HuangThe Affiliated Hospital of Shaanxi University of Chinese Medicine, No.2 Weiyang Road, Xianyang, 712046, Shaanxi, People's Republic of China.
Lin LiuDepartment of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 666, Jianyuan 2nd Road, Xi'an, 710054, Shaanxi Province, People's Republic of China.
Zhaohui YiOrthopedics Department, the Hospital of Zhenping County, No.38 Jiangbei Road, Ankang, 725600, Shaanxi, People's Republic of China.
Hongchao YuThe Affiliated Hospital of Shaanxi University of Chinese Medicine, No.2 Weiyang Road, Xianyang, 712046, Shaanxi, People's Republic of China.
Zhi YangDepartment of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 666, Jianyuan 2nd Road, Xi'an, 710054, Shaanxi Province, People's Republic of China. hhyy_yangzhi@163.com.

Funding

Natural Science Basic Research Program of Shaanxi Province 2024JC-YBQN-0896Project of Xi'an Municipal Health Commission 2024qn11the NSFC Seed Funding Project of Xi'an Honghui Hospital 2025zz-qn01
6 · The paper itself

Abstract

Piezo1 is a mechanically activated, non-selective cation channel characterized by its exquisite sensitivity to membrane tension and high permeability to calcium(Ca

Indexed as

FerroptosisIon ChannelsAnimalsCalciumHumansIronLipid PeroxidationMechanotransduction, CellularReactive Oxygen SpeciesSignal TransductionCalciumIon ChannelsIronPIEZO1 protein, humanReactive Oxygen SpeciesCalcium influxFerroptosisGPX4 inactivationIron metabolism reprogrammingPiezo1

Identifiers

PMID41854751
PMCPMC13002675

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.