Evidence map›Paper›PMID 41854754›Full record

ArticleMolecular biology reports2026

Pro-oxidant effect of lobaric acid as a therapeutic strategy against breast cancer: a molecular perspective.

Emine Toraman, Şeyda Nur Kalın, Kübra Nur Bayındırlı, Şükran Günaydın, Fatmanur Keleş, Ahmet Altay, Harun Budak

Abstract read
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In one paragraph

Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emine ToramanScience Faculty, Department of Molecular Biology and Genetics, Atatürk University, Erzurum, 25240, Turkey.
Şeyda Nur KalınScience Faculty, Department of Molecular Biology and Genetics, Atatürk University, Erzurum, 25240, Turkey.
Kübra Nur BayındırlıScience Faculty, Department of Molecular Biology and Genetics, Atatürk University, Erzurum, 25240, Turkey.
Şükran GünaydınScience Faculty, Department of Molecular Biology and Genetics, Atatürk University, Erzurum, 25240, Turkey.
Fatmanur KeleşScience Faculty, Department of Molecular Biology and Genetics, Atatürk University, Erzurum, 25240, Turkey.
Ahmet Altay *Faculty of Science and Arts, Department of Chemistry, Erzincan Binali Yıldırım University, Erzincan, 24002, Turkey. aaltay@erzincan.edu.tr.
Harun Budak *Science Faculty, Department of Molecular Biology and Genetics, Atatürk University, Erzurum, 25240, Turkey. hbudak@atauni.edu.tr.

Funding

TÜBİTAK 1002 projects 119Z112
6 · The paper itself

Abstract

backgroundThis study aimed to investigate the anticancer effects of lobaric acid (LA), a lichen acid, in MCF-7 cells. Our previous study demonstrated that LA exhibits anticancer effects by triggering apoptosis in MCF-7 cells. However, the relationship between this anticancer effect and the oxidative pathway and apoptosis mechanism has not been explained. In this study, the cytotoxic and anticancer effects of LA on MCF-7 cells were investigated through oxidative stress and thioredoxin system pathways. METHODS AND

resultsFor this purpose, reactive oxygen species (ROS), reduced glutathione (GSH), and malondialdehyde (MDA) levels were measured in MCF-7 cells exposed to LA at a concentration of 44.21 µg/mL (IC50). Additionally, the activities, gene, and protein levels of SOD, CAT, GPx, GST, GR, and TrxR enzymes were evaluated. In addition, the expression levels of TXN and TXNIP genes were also analyzed. The results showed that LA increased ROS and MDA levels and decreased GSH levels. Antioxidant enzyme activities (SOD, CAT, GR, TrxR) and protein levels decreased compared to the control, while heterogeneous changes were observed in gene expression levels. Despite increased GPX gene expression, a decrease in enzyme activity and protein levels was observed. While no change in TXN gene expression was observed, protein levels were decreased. TXNIP protein levels were also decreased.

conclusionsThe findings provide important data for evaluating lichen-derived compounds as potential anticancer agents targeting redox balance.

Indexed as

Breast NeoplasmsCyclobutanesSalicylatesAntineoplastic AgentsAntioxidantsApoptosisCarrier ProteinsCatalaseDepsidesFemaleGene Expression Regulation, NeoplasticGlutathioneGlutathione PeroxidaseHumansLactonesMalondialdehydeAntineoplastic AgentsAntioxidantsCarrier ProteinsCatalaseCyclobutanesDepsidesGlutathioneGlutathione PeroxidaseLactoneslobaric acidMalondialdehydeReactive Oxygen SpeciesSalicylatesSuperoxide DismutaseThioredoxinsTXNIP protein, humanLobaric acidMCF-7Oxidative stressThioredoxin system

Identifiers

PMID41854754

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.