ArticleJournal of diabetes investigation2026
Evaluation of %CV and average glucose derived from pre- and postprandial 6-point glucose measurements for assessing hypoglycemia risk.
Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
AIMS/
introductionThis study determined the usefulness of coefficient of variation (%CV) and average glucose (AG) from 6-point pre- and postprandial blood glucose measurements in assessing hypoglycemia risk in type 2 diabetes. MATERIALS AND
methodsWe retrospectively analyzed 24-h continuous glucose monitoring data of 233 patients treated with sulfonylureas or insulin. Hypoglycemia was defined as level 1 (<70 mg/dL) or level 2 (<54 mg/dL).
resultsThe 6-point AG and %CV were 182.9 mg/dL and 23.9%, respectively, for all patients, whereas they were 155.8 mg/dL and 29.8% in patients with level 1 hypoglycemia. Receiver operating characteristic analysis determined cutoff values of 167.7 mg/dL for AG and 21.6% for %CV for predicting level 1 hypoglycemia. Using these thresholds as hypoglycemia risk factors, the incidence was evaluated in the three groups according to the number of risk factors. The incidence of both levels 1 and 2 hypoglycemia increased significantly with increase in the number of risk factors. Compared to risk factor-free patients, the odds ratios for level 1 hypoglycemia were 12.1 and 1.4 in those with two and one risk factor, respectively.
conclusionsOur findings suggest that the AG and %CV derived from 6-point glucose measurements can be potentially useful for detecting hypoglycemia risk.
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