Evidence mapPaperPMID 41855263Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Gut microbe-derived

Sumita Dutta, Kala K Mahen, William J Massey, Venkateshwari Varadharajan, Amy C Burrows, Anthony J Horak, Marko Mrdjen, Nour Mouannes, Danny Orabi, Lucas J Osborn and 19 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Sumita Dutta *Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0001-7538-1045
Kala K Mahen *Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.
William J Massey *Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-2087-6048
Venkateshwari VaradharajanDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-4557-9840
Amy C BurrowsDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.
Anthony J HorakDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0009-0009-2024-3679
Marko MrdjenDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.
Nour MouannesDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0003-4941-555X
Danny OrabiCenter for Microbiome and Human Health, Cleveland Clinic Research, Cleveland, OH 44195.
Lucas J OsbornDepartment of Heart, Blood, and Kidney Research, Cleveland Clinic Research, Cleveland, OH 44195.
Treg GrubbDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-3388-758X
Rachel C HoheDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-4809-753X
Rakhee BanerjeeDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-2299-7177
Vinayak UppinDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-0338-1983
Dev LaunganiDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.
Grace E HamiltonDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0003-2551-3796
Xiayan YeDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.
Naseer SangwanCenter for Microbiome and Human Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-2407-769X
Mohammed DwidarCenter for Microbiome and Human Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0003-1366-0393
Adeline M HajjarCenter for Microbiome and Human Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-4838-8070
Belinda WillardProteomics Core Facility, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0001-6884-6369
Michael MartinCayman Chemical, Ann Arbor, MI 48108.ORCID 0000-0001-9727-9893
Erik GuetschowCayman Chemical, Ann Arbor, MI 48108.
Patrick WestcottCayman Chemical, Ann Arbor, MI 48108.ORCID 0009-0004-7351-8166
Megan R McMullenDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0009-0007-6020-7125
Laura E NagyDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-0580-2809
Zeneng WangCenter for Microbiome and Human Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-6455-8228
Stanley L HazenCenter for Microbiome and Human Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0001-7124-6639
J Mark BrownDepartment of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0003-2708-7487

Funding

Project 4 Title: Innate immunity and cell death in ALDP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · 2021 to 2025
$5.0M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · 2023 to 2025
$3.6M
Dark GPCR signaling underlying the Microbiome-Gut-Brain Axis for Alzheimer's Disease and Related DementiaRF1NS133812 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Jonathan Mark Brown, Feixiong Cheng · 2023 to 2023
$2.3M
Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic DiseaseR01HL179780 · CLEVELAND CLINIC LERNER COM-CWRU · 2025 to 2025
$743k
American Heart Association (AHA) 24POST1178494Cleveland Clinic (CC) N/ANHLBI NIH HHS P01 HL147823NHLBI NIH HHS R01 HL179780NIAAA NIH HHS P50 AA024333NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK130227NINDS NIH HHS RF1 NS133812ODCDC CDC HHS S10 OD030398
6 · The paper itself

Abstract

Although strong evidence links the gut microbiome to metabolic disease, the mechanisms linking microbiota to hormonal and metabolic responses to food are not well understood. After a meal, gut bacteria produce a wide array of small molecule, protein, and lipid metabolites originating from bacterial sources. Attributing physiological function to select gut microbe-derived metabolites is critical to understanding diet-microbe-host interactions, and to developing microbiome-inspired therapies to improve human health. Here, we have investigated the role of a poorly annotated class of gut microbiome-derived lipids called

Indexed as

Gastrointestinal MicrobiomeHomeostasisLipidsPostprandial PeriodAmidesAnimalsHumansLipid MetabolismMiceAmidesLipidscircadianhormonelipidmetabolismmicrobiome

Identifiers

PMID41855263
PMCPMC13012048

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.