Evidence map›Paper›PMID 41857047›Full record

ArticleNature communications2026

FGF1 orchestrates circadian hepatic triglyceride secretion.

Benan Pelin Sermikli, Sihao Liu, Kyeongkyu Kim, Linnea Hases, Tim van Zutphen, Ashley Untereiner, Jocelyn Torres, Mingxiao He, Lillian Crossley, Yang Dai and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Benan Pelin Sermikli *Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9930-1919
Sihao Liu *Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Kyeongkyu KimGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Linnea HasesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6741-7204
Tim van ZutphenDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ashley UntereinerGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jocelyn TorresGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0009-0007-2892-2786
Mingxiao HeGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Lillian CrossleyGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Yang DaiGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jonathan ZhuGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7074-0459
Chandra Lekha KoopariGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Weiwei FanGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Morgan L TruittGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Johan W JonkerDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Annette R AtkinsGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. downes@salk.edu.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. evans@salk.edu.ORCID http://orcid.org/0000-0002-9986-5965

Funding

Tissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2020 to 2024
$12.2M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
Hormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6M
Larry L. Hillblom Foundation (Larry L. Hillblom Foundation, Inc.) 2021-D-001-NETMarch of Dimes Foundation (March of Dimes) EvansNHLBI NIH HHS P01 HL147835NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK057978NOMIS Stiftung (NOMIS Foundation) Distinguished Scholar AwardU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL147835
6 · The paper itself

Abstract

Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) represents a global health crisis associated with dysregulated hepatic triglyceride (TG) synthesis, oxidation and secretion. Despite progress in targeting hepatic lipid synthesis/oxidation for MASLD treatment and a well-documented relationship between circadian rhythms and lipid metabolism, the adaptive mechanisms coordinating TG secretion with circadian timing remain incompletely understood. Here we identify an autocrine regulatory pathway where circadian hepatic Fibroblast Growth Factor 1 (Fgf1) expression synchronizes diurnal TG secretion with the active phase. FGF1 activation of FGFR4 induces an mTORC1-IRE1-XBP1 signaling cascade involving atypical IRE1 activation that promotes TG secretion. Consistently, dietary-driven MASLD is exacerbated in liver-specific FGF1 knockout mice, while exogenous FGF1 halts disease progression in a Metabolic dysfunction-Associated Steatohepatitis (MASH) mouse model. This study causally associates FGF1 circadian rhythmicity with TG secretion to establish FGF1 as a crucial pacemaker in hepatic lipid homeostasis.

Indexed as

Circadian RhythmFibroblast Growth Factor 1LiverTriglyceridesAnimalsDisease Models, AnimalEndoribonucleasesFatty LiverLipid MetabolismMaleMechanistic Target of Rapamycin Complex 1Membrane ProteinsMiceMice, Inbred C57BLMice, KnockoutProtein Serine-Threonine KinasesEndoribonucleasesErn1 protein, mouseFgfr4 protein, mouseFibroblast Growth Factor 1Mechanistic Target of Rapamycin Complex 1Membrane ProteinsProtein Serine-Threonine KinasesReceptor, Fibroblast Growth Factor, Type 4TriglyceridesX-Box Binding Protein 1Xbp1 protein, mouse

Identifiers

PMID41857047
PMCPMC13168322

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.