Evidence map›Paper›PMID 41857429›Full record

ArticleNature metabolism2026

Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway.

Shuke Xiao, Mengjie Wang, Thomas G Martin, Barry Scott, Xing Fang, Xinming Liu, Yongjie Yang, Sipei Fu, Steven D Truong, Jack F Gugel and 21 more

Abstract read
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Shuke Xiao *Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2103-128X
Mengjie Wang *USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Thomas G Martin *Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA.
Barry ScottSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-8841-3525
Xing FangUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Xinming LiuUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Yongjie YangUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Sipei FuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Steven D TruongDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Jack F GugelDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA.
Gregory L MaasDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA.
Marcus P MullenBioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Jennifer Hampton HillDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA.
Veronica L LiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8888-3853
Andrew L MarkhardDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Mingming ZhaoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Wei QiDepartment of Biology, Stanford University, Stanford, CA, USA.
Saranya C ReghupatyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Meng ZhaoDepartment of Animal Science, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-5415-8335
Jan SpaasDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Wei WeiDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-8110-0705
Trine MoholdtDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-1024-8088
John A HawleyExercise & Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0002-0886-9881
Christian T VoldstedlundThe August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6368-8995
Erik A RichterThe August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6850-3056
Xiaoke ChenDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9032-9093
Katrin J SvenssonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5376-5128
Daniel BernsteinDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7761-5853
Leslie A LeinwandDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA. leslie.leinwand@colorado.edu.ORCID http://orcid.org/0000-0003-1470-4810
Yong XuUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. yongx@bcm.edu.ORCID http://orcid.org/0000-0002-4908-1572
Jonathan Z LongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA. jzlong@stanford.edu.ORCID http://orcid.org/0000-0003-2631-7463

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
MYOSIN GENE DIVERSITY AND FUNCTIONR01GM029090 · NIGMS · YESHIVA UNIVERSITY · PI Leslie Anne Leinwand · 1985 to 2026
$12.3M
Predoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3M
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
Mechanisms controlling fructose uptake and utilizationR01DK125260 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2020 to 2026
$3.5M
Chemical control of energy metabolism by N-acyl amino acidsR01DK124265 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2020 to 2024
$2.0M
A CHOLINERGIC NEUROCIRCUIT REGULATES FEEDING BEHAVIORR01DK138518 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, YONG XU · 2024 to 2026
$1.9M
Control of obesity by an appetite-suppressing peptideR01DK142416 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2026 to 2026
$783k
CIRCULATING FACTORS THAT REGULATE BROWN AND BEIGE FATR00DK105203 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2018 to 2020
$728k
PERIFORNICAL AREA OF THE ANTERIOR HYPOTHALAMUS REGULATES METABOLIC BALANCEF32DK138685 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Xing Fang · 2024 to 2026
$257k
Investigating Isthmin as an adipose-to-muscle messenger that promotes muscle protein synthesisK99AR081618 · NIAMS · STANFORD UNIVERSITY · PI ZHAO, MENG · 2023 to 2024
$182k
NHLBI NIH HHS F32 HL170637NIAMS NIH HHS K99 AR081618NICHD NIH HHS F32 HD112123NIDDK NIH HHS F32 DK138685NIDDK NIH HHS K99 DK141966NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R00 DK105203NIDDK NIH HHS R01 DK124265NIDDK NIH HHS R01 DK125260NIDDK NIH HHS R01 DK138518NIDDK NIH HHS R01 DK142416NIGMS NIH HHS R01 GM029090NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM065103NIGMS NIH HHS T32 GM142607U.S. Department of Health Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes Digestive Kidney Diseases) K99DK141966U.S. Department of Health Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes Digestive Kidney Diseases) R01DK124265
6 · The paper itself

Abstract

Most mammals consume small and frequent meals. By contrast, pythons are ambush predators that exhibit extreme feeding and fasting patterns and provide a unique model for uncovering molecular mediators of the postprandial response

Indexed as

BoidaeBrainFeeding BehaviorGastrointestinal TractMetabolomicsPostprandial PeriodAnimalsEatingHumansMaleMice

Identifiers

PMID41857429
PMCPMC13121007

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.