Evidence map›Paper›PMID 41857689›Full record

ReviewJournal of animal science and biotechnology2026

CRISPR-enhanced microalgae biosynthesis: a promising approach for future functional feed ingredients.

Zhen Li, Cong Li, Huan Liu, Yihao Wang, Yahui Sun, De-Xing Hou, Jianhua He, Shusong Wu

Abstract readReview
In one paragraph

Review in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhen Li *Yuelushan Laboratory, Hunan Agricultural University, Changsha, 410128, China.
Cong Li *Yuelushan Laboratory, Hunan Agricultural University, Changsha, 410128, China.
Huan LiuYuelushan Laboratory, Hunan Agricultural University, Changsha, 410128, China.
Yihao WangYuelushan Laboratory, Hunan Agricultural University, Changsha, 410128, China.
Yahui SunSchool of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing, 210023, China.
De-Xing HouDepartment of Food Science and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima, 890-0065, Japan.
Jianhua HeYuelushan Laboratory, Hunan Agricultural University, Changsha, 410128, China. jianhuahy@hunau.net.
Shusong WuYuelushan Laboratory, Hunan Agricultural University, Changsha, 410128, China. wush688@hunau.edu.cn.ORCID http://orcid.org/0000-0003-3532-1165

Funding

National Key Research and Development Program of China 2023YFD1302300National Natural Science Foundation of China U25A20706Yuelushan Laboratory Breeding Program YLS-2025-ZY04009
6 · The paper itself

Abstract

Microalgae are photosynthetic microorganisms capable of synthesizing diverse high-value bioactive compounds, including premium proteins, polyunsaturated fatty acids, pigments, and vitamins. These natural products exhibit significant potential in enhancing livestock growth and health, offering biological activity and nutritional benefits that surpass chemically synthesized alternatives. Nevertheless, the commercial production of microalgae-derived natural products remains insufficient to meet escalating market demands. Utilizing synthetic biology strategies, especially the CRISPR system, to increase productivity of microalgae cell factories is crucial for scaling up high-value product biosynthesis. This article reviews the current applications, construction strategies, and critical pathway nodes in microalgae cell factory, with emphasis on CRISPR-based genome editing breakthroughs for optimizing microalgae nutritional profiles, and recent progress in microalgae utilization for livestock production, providing a forward-looking perspective on future developments.

Indexed as

BiosynthesisCRISPRFeedGenome editingMicroalgaeSustainability

Identifiers

PMID41857689
PMCPMC13003683

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.