Evidence map›Paper›PMID 41857751›Full record

ArticleJournal of ovarian research2026

Clinical significance of CD27

Sila Uluturk, Isilay Akdag Aras, Vildan Altahhan, Vefa Sakar, Berkan Karadurmus, Mehmet Mert Hidiroglu, Sumeyra Guler, Ibrahim Burak Bahcecioglu, Ozhan Ozdemir, Ismail Erturk and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sila UluturkDepartment of Basic Oncology, Cancer Institute, Hacettepe University, Ankara, Turkey.
Isilay Akdag ArasDepartment of Basic Oncology, Cancer Institute, Hacettepe University, Ankara, Turkey.
Vildan AltahhanDepartment of Obstetrics and Gynecology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Vefa SakarDepartment of Obstetrics and Gynecology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Berkan KaradurmusDivision of Medical Oncology, Department of Internal Medicine, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Mehmet Mert HidirogluDepartment of General Surgery, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Sumeyra GulerDepartment of Surgical Oncology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Ibrahim Burak BahceciogluDepartment of Surgical Oncology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Ozhan OzdemirDepartment of Obstetrics and Gynecology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Ismail ErturkDivision of Medical Oncology, Department of Internal Medicine, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Mehmet Ali GulcelikDepartment of Surgical Oncology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Kerim Bora YilmazDepartment of General Surgery, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Gunes EsendagliDepartment of Basic Oncology, Cancer Institute, Hacettepe University, Ankara, Turkey. gunese@hacettepe.edu.tr.ORCID http://orcid.org/0000-0003-4865-2377

Funding

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 2211 National PhD Scholarship Programme (Application No. 1649B032205227)
6 · The paper itself

Abstract

objectiveOvarian cancer remains the most lethal gynaecological malignancy, and the identification of reliable biomarkers for determining treatment responses and prognosis is needed. This study investigated the clinical significance of helper and cytotoxic effector memory T-cell (T

methodsMulti-parametric flow cytometry was used to analyse peripheral blood (n = 30), ascites (n = 14) and tumour tissue (n = 31) from patients with high-grade ovarian cancer (FIGO III-C, n = 31) and age-matched healthy controls (n = 16). Subsets were stratified by histopathology, neoadjuvant chemotherapy status, and clinical outcomes.

resultsT

conclusionThe preservation of CD27 and CD28 on circulating T

Indexed as

Biomarkers, TumorCD28 AntigensMemory T CellsOvarian NeoplasmsTumor Necrosis Factor Receptor Superfamily, Member 7AdultAgedFemaleHumansImmunologic MemoryMiddle AgedPrognosisTumor MicroenvironmentBiomarkers, TumorCD28 AntigensTumor Necrosis Factor Receptor Superfamily, Member 7memory T cellsmicroenvironmenttumour-infiltrating lymphocytes

Identifiers

PMID41857751
PMCPMC13154613

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.