Evidence map›Paper›PMID 41858165›Full record

ArticleJournal of immunology research2026

Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma.

Shubhanshi Trivedi, Samuel E Aamodt, Thomas P Huecksteadt, Elizabeth J Myers, Grace Helen McGee, Jackson G Cacioppo, Jeffrey Aubé, Robert Paine, Daniel T Leung, Kristi J Warren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shubhanshi TrivediDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.ORCID https://orcid.org/0000-0001-6891-2290
Samuel E AamodtDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.
Thomas P HuecksteadtGeorge E Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Elizabeth J MyersDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.
Grace Helen McGeeDepartment of Pathology, University of Utah, Salt Lake City, Utah, USA, utah.edu.ORCID https://orcid.org/0009-0009-3484-9858
Jackson G CacioppoDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, unc.edu.
Jeffrey AubéDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, unc.edu.ORCID https://orcid.org/0000-0003-1049-5767
Robert PaineDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.
Daniel T LeungDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.ORCID https://orcid.org/0000-0001-8401-0801
Kristi J WarrenDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA, utah.edu.ORCID https://orcid.org/0000-0003-0680-4037

Funding

Amnis ImageStreamX MarkII Imaging Flow CytometerS10OD026959 · OD · UNIVERSITY OF UTAH · PI MARVIN, JAMES E · 2020 to 2020
$517k
NCI NIH HHS 5P30CA042014-24NIH HHS S10OD026959U.S. Department of Veterans Affairs 5I01 BX004637U.S. Department of Veterans Affairs IK2 BX4004219
6 · The paper itself

Abstract

Asthma affects over 300 million people worldwide, with increasing rates annually. Males have higher asthma prevalence in adolescence, while females exhibit higher rates in adulthood. Reduced mucosal-associated invariant T (MAIT) cells are found in severe asthmatic airway disease. We hypothesize MAIT cells modulate airway inflammation and are regulated by sex hormones through their cognate hormone receptors. We compared circulating MAIT cells and ex vivo MAIT cell activation with MR-1 ligand in controls and asthmatic individuals. MAIT cells were significantly lower in asthmatic males and females compared to healthy controls. MAIT cells derived from male and female asthma patients exhibited higher levels of estrogen receptors (ERs) than those from sex-matched healthy controls, and ex vivo treatment with estrogen significantly decreased IFN-γ production in asthmatics. Estrogen treatment did not reduce IFN-γ in MAIT cells from healthy individuals. To explore the effect of estrogen on MAIT cells, we used the murine Alternaria alternata challenge model. Adoptive transfer of G-protein coupled ER (GPER-1) antagonist (G36)-treated MAIT cells into Rag1 knockout mice (Rag1

Indexed as

AsthmaEstrogensMucosal-Associated Invariant T CellsAdultAnimalsDisease Models, AnimalFemaleHomeodomain ProteinsHumansInterferon-gammaLymphocyte ActivationMaleMiceMice, KnockoutMiddle AgedReceptors, EstrogenEstrogensGPER1 protein, humanHomeodomain ProteinsInterferon-gammaRAG-1 proteinReceptors, EstrogenReceptors, G-Protein-Coupledasthmaestrogen (E2)estrogen receptors (ER) α and ERβG-protein coupled estrogen receptor (GPER-1)interleukin-2 (IL-2) IL-7 IL-12 IL-15 IL-18mucosal-associated invariant T (MAIT) cells

Identifiers

PMID41858165
PMCPMC13140411

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.