Evidence mapPaperPMID 41858245Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond.

Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S M Shatil Shahriar, Jingwei Xie

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Syed Muntazir AndrabiDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Navatha Shree SharmaDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Imran Ibn Gani RatherDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, USA.
S M Shatil ShahriarDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Jingwei XieDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-8126-1397

Funding

Congressionally Directed Medical Research ProgramsNebraska Research Initiative NE LB606NIDCR NIH HHS R01GM123081andR01DE031272NIGMS NIH HHSPeer Reviewed Medical Research Program FY19 W81XWH2010207University of Nebraska Medical Center
6 · The paper itself

Abstract

Gaseous mediators are increasingly recognized as critical regulators of human physiology and pathology, offering unique therapeutic opportunities that are fundamentally constrained by challenges in controlled delivery, spatial targeting, and biological specificity when harnessed through advanced delivery technologies. Among them, nitric oxide (NO) has emerged as a central player. Recent advancements have transitioned from conventional donor-based systems with limited control over dose and localization to wearable gas-delivery platforms capable of real-time, patient-specific dosing and frequently coupling with embedded diagnostic functionalities for dynamic feedback and precision control. Importantly, the therapeutic scope of gas biology is expanding beyond NO to encompass other clinically relevant and emerging gases, including O

Indexed as

Drug Delivery SystemsGasesNitric OxideAnimalsHumansGasesNitric Oxidebiomedicinedeliverydonorsgaseous mediatorsnitric oxidephysiological functions

Identifiers

PMID41858245
PMCPMC13104097

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.