Evidence map›Paper›PMID 41858740›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

The glycan fingerprint in immune thrombocytopenia.

Vivianne S Nelson, Jan Zlamal, Rick Kapur

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vivianne S NelsonSanquin Blood Supply Foundation, Department Research, and Amsterdam UMC location University of Amsterdam, Landsteiner Laboratory, Amsterdam, The Netherlands.
Jan ZlamalInstitute for Clinical and Experimental Transfusion Medicine, University Hospital of Tübingen, Tübingen, Germany.
Rick KapurSanquin Blood Supply Foundation, Department Research, and Amsterdam UMC location University of Amsterdam, Landsteiner Laboratory, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A state-of-the-art lecture titled "Platelet Glycobiology and Immune Thrombocytopenia (ITP)" was presented at the International Society on Thrombosis and Haemostasis (ISTH) congress in 2025. In this review, we summarize the current knowledge on glycan-mediated mechanisms in ITP, including glycan alterations of platelet autoantibodies and on the surface of platelets and megakaryocytes. We discuss how these glycan modifications might contribute to thrombocytopenia, and potentially to an increased risk of bleeding in patients with ITP. We address relevant new data on this topic and emphasize key directions for future ITP glycobiology research.

Indexed as

Fc-glycosylationglycobiologyglycosylationimmune thrombocytopeniaITPplatelet autoantibodiesplatelet desialylation

Identifiers

PMID41858740
PMCPMC12995902

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.