Evidence map›Paper›PMID 41858776›Full record

ArticleFrontiers in cell and developmental biology2026

DNA2 acts as a brake on β cell insulin hypersecretion and diet-induced metabolic dysfunction.

Haixia Xu, Dongmei Tang, Na Yang, Meilin Ma, Yan Tian, Xianghui Fu

Abstract read
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In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haixia Xu *State Key Laboratory of Biotherapy and Cancer Center, Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Dongmei Tang *State Key Laboratory of Biotherapy and Cancer Center, Department of Biotherapy, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Na YangState Key Laboratory of Biotherapy and Cancer Center, Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Meilin MaState Key Laboratory of Biotherapy and Cancer Center, Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yan TianState Key Laboratory of Biotherapy and Cancer Center, Department of Biotherapy, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xianghui FuState Key Laboratory of Biotherapy and Cancer Center, Department of Biotherapy, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: DNA replication helicase/nuclease 2 (DNA2) is an evolutionarily conserved nuclease-helicase with known role in maintaining nuclear genome stability. However, its potential involvement in metabolic regulation and disease remains unclear. This study investigates the role of DNA2 in pancreatic β cell physiology and diabetes pathogenesis. Methods: β cell-specific DNA2 knockout mice (DNA2 Results: DNA2 Conclusion: Our findings identify DNA2 as a negative regulator of mitochondrial bioenergetics and insulin secretion in β cells. By limiting mitochondrial activity, DNA2 serves as a rheostat that prevents β cell overactivation during metabolic stress, thereby preserving systemic glucose homeostasis.

Indexed as

DNA2hyperinsulinemiainsulin secretionmitochondrial activityβ cell proliferation

Identifiers

PMID41858776
PMCPMC12996210

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.