Evidence map›Paper›PMID 41858908›Full record

Trial reportDrug design, development and therapy2026

Liposomal Bupivacaine for Adductor Canal Block Combined with IPACK Block in Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial.

Qisong Yuan, Wang Shen, Wenbin He, Xiaomin Wang, Feng Liu, Yi Zhang, Xinge Lu, Zhaoming Guan, Jinyuan Zhang, Longqiu Yang

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07509866 (A Randomized Trial of Liposomal Bupivacaine, Ropivacaine With Perineural Dexamethasone, and Ropivacaine With Perineural Dexmedetomidine for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07509866 narecruitingnot on this map

A Randomized Trial of Liposomal Bupivacaine, Ropivacaine With Perineural Dexamethasone, and Ropivacaine With Perineural Dexmedetomidine for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty

TypeinterventionalSponsorHuazhong University of Science and TechnologyRan2026 to 2026Enrolled90ConditionsTotal Knee Anthroplasty, Nerve Block, Ropivacaine, Liposomal BupivacaineArmsLiposomal bupivacaine (LB), Ropivacaine with Perineural Dexamethasone, Ropivacaine with Perineural Dexmedetomidine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qisong Yuan *Department of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Wang Shen *Department of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID 0000-0002-2440-9631
Wenbin HeDepartment of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID 0000-0002-0055-5204
Xiaomin WangDepartment of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Feng LiuDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Yi ZhangDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Xinge LuDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Zhaoming GuanDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID 0009-0008-6039-6592
Jinyuan ZhangDepartment of Pain, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Longqiu YangDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.ORCID 0009-0000-5641-2360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Patients undergoing total knee arthroplasty (TKA) may experience severe postoperative pain despite preoperative nerve blocks. This study aims to investigate the effect of liposomal bupivacaine (LB) for adductor canal block (ACB) combined with infiltration between the popliteal artery and the posterior knee capsule (iPACK) in TKA. Patients and Methods: This prospective, double-blind, randomized controlled trial was conducted from March 2025 to August 2025 in a Chinese tertiary hospital. 86 patients aged 18-90 years, classified as the American Society of Anesthesiologists (ASA) Physical Status I-III and undergoing TKA, were randomly assigned to either the liposomal bupivacaine group (Group LB) or ropivacaine group (Group R). All patients underwent ACB combined with iPACK block administered with either LB or ropivacaine preoperatively. The primary outcome was visual analog scale (VAS) at multiple time points under three conditions: at rest, during maximum knee flexion, and during ambulation. Secondary outcomes included opioids consumption, knee range of motion (ROM), quadriceps strength, the Timed Up-and-Go (TUG) test within the first 3 days, as well as the American Knee Society (AKS) score and the Quality of Recovery-15 (QoR-15) score assessed at 2 weeks and 1 month. Results: Demographic and baseline characteristics were comparable between groups (P>0.05). The VAS scores in Group LB were significantly lower than those in Group R at 24h, 48h, and 72h across all assessment conditions ( Conclusion: Liposomal Bupivacaine for adductor canal block combined with IPACK block provided no clinically significant benefit in patients undergoing total knee arthroplasty.

Indexed as

Anesthetics, LocalArthroplasty, Replacement, KneeBupivacaineNerve BlockPostoperative PainAdolescentAdultAgedAged, 80 and overDouble-Blind MethodFemaleHumansLiposomesMaleMiddle AgedProspective StudiesAnesthetics, LocalBupivacaineLiposomesadductor canal blockiPACK blockliposomal bupivacainetotal knee arthroplasty

Identifiers

PMID41858908
PMCPMC12998302

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.