Evidence mapPaperPMID 41859007Full record

ArticleMolecular therapy. Oncology2026

Deficiencies in the Fanconi anemia or homologous recombination pathway enhance the antitumor effects of the hypoxia-activated prodrug CP-506.

Lesley Schuitmaker, Alexander M A van der Wiel, Natasja G Lieuwes, Rianne Biemans, Nikki A M Mutsters, Jennifer Jung, Victoria Claudino Bastos, Èlia Prades Sagarra, Sheng Kuang, Jeremy Setton and 6 more

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lesley SchuitmakerDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Alexander M A van der WielDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Natasja G LieuwesDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Rianne BiemansDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Nikki A M MutstersDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Jennifer JungDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Victoria Claudino BastosDepartment of Pharmacology and Toxicology, Research Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6221 ER Maastricht, the Netherlands.
Èlia Prades SagarraDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Sheng KuangDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Jeremy SettonDepartment of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Sabine A S LangieDepartment of Pharmacology and Toxicology, Research Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6221 ER Maastricht, the Netherlands.
Kim R KampenDepartment of Radiation Oncology (MAASTRO), Maastricht University Medical Center, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Jan TheysDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Ala YarominaDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Ludwig J DuboisDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.
Philippe LambinDepartment of Precision Medicine, Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6221 ER Maastricht, the Netherlands.

Funding

The Patient-Reported Outcomes, Community-Engagement and Language (PRO-CEL) CoreP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · 1985 to 2025
$88.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The novel hypoxia-activated prodrug CP-506 selectively targets the hypoxic, treatment-resistant tumor microenvironment. Given the alkylating effector metabolites of CP-506, we hypothesized that defects in interstrand crosslink (ICL) and double-strand break repair influence treatment efficacy.

Indexed as

biomarkercancerDNA repairFanconi anemia deficiencyhomologous recombination deficiencyhypoxiahypoxia-activated prodrugsMT: Regular Issueprecision medicinesynthetic lethality

Identifiers

PMID41859007
PMCPMC12995515

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.