Evidence map›Paper›PMID 41859136›Full record

ArticleFrontiers in medicine2026

Risk factors of histologic upgrade between colposcopy-directed biopsy and loop electrosurgical excision procedure in cervical squamous intraepithelial lesions: a retrospective study.

Yuan Ma, Bowen Xu, Tingting Zhang, Yong Zhi, Heling Ma, Yuanbo Ling, Jie Xu, Liyan Sun, Fang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuan Ma *Department of Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Bowen Xu *Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Tingting ZhangDepartment of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yong ZhiDepartment of Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Heling MaDepartment of Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yuanbo LingDepartment of Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Jie XuDepartment of Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Liyan SunDepartment of Gynecology, People's Hospital of Pudong New Area, Shanghai, China.
Fang LiDepartment of Gynecology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study is to compare the pathological outcomes between colposcopy-directed biopsy (CDB) and loop electrosurgical excision procedure (LEEP) in patients diagnosed with cervical squamous intraepithelial lesions (SIL), and to evaluate the risk factors correlated with histologic upgrade from CDB to subsequent LEEP conization. Methods: This retrospective study included a total of 1,496 patients who underwent LEEP after receiving pathological confirmation of cervical SIL through CDB. Statistical analysis was employed to assess the risk factors associated with the histologic upgrade of biopsy. Results: The study cohort was composed of 410 patients initially categorized with LSIL and 1,086 identified with HSIL, who subsequently underwent LEEP surgery. Among the LSIL-patients diagnosed via CDB, 79 showed instances of biopsy histologic upgrade. The analysis revealed that HPV16 ( Conclusion: Our study identified that HPV16/18 infection and a non-fully visible cervical transformation zone are significant risk factors associated with histologic upgrade between CDB and subsequent LEEP conization.

Indexed as

cervical squamous intraepithelial lesionscolposcopy-directed biopsyhistolofic upgradeHPV16/18 infectionloop electrosurgical excision procedure

Identifiers

PMID41859136
PMCPMC12996164

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.