Evidence map›Paper›PMID 41859393›Full record

ArticleJournal of inflammation research2026

Aging Inhibits Emergency Angiogenesis and Exacerbates Neuronal Damage by Downregulating DARS2.

Dan Liu, Meilin Weng, Rui Wang, Wenchao Fu, Lijuan Zhang, Cheng Wang, Mingsen Liu, Tao Shen, Jirui Ren, Yinfei Song and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dan LiuDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.ORCID 0000-0001-7698-6978
Meilin WengDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Rui WangDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Wenchao FuDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.
Lijuan ZhangDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.
Cheng WangDepartment of Environmental Hygiene, School of Public Health, Harbin Medical University, Harbin, People's Republic of China.
Mingsen LiuDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.
Tao ShenDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.
Jirui RenDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.
Yinfei SongDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.
Jiayu LiDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.
Xianzhang ZengDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, The Heilongjiang Key Laboratory of Anesthesia and Intensive Care Research, Harbin Medical University, Harbin, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early vascular regeneration is important for the speedy recovery of neurological function following ischemic stroke. M2-like microglia polarization decreases and vascular regeneration weakens with aging. The function of mitochondrial respiratory chain is dependent on M2-like polarization in microglia. Methods: A murine model of middle cerebral artery occlusion (MCAO) was used to perform animal behavioral assessments, immunoblotting, tube formation and chick embryo chorioallantoic membrane assays. A D-galactose-induced cellular senescence model was established in BV2 cells. Results: Aging significantly exacerbates acute brain injury 24 hours post-cerebral ischemia-reperfusion, with increased expression of M1-like microglial markers and a concomitant decrease in M2-like microglial markers. Additionally, aging can inhibit DARS2 protein expression, adversely affect angiogenesis and reduce brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor A (VEGFA) expression. In vitro, oxygen-glucose deprivation/reoxygenation and re-glucose (OGD/R) demonstrated that Conclusion: This study suggests that aging impedes M2-like microglial polarization by downregulating DARS2 expression in microglia, thereby impairing emergency angiogenesis during acute ischemic stroke and exacerbating neuronal damage.

Indexed as

angiogenesisDARS2ischemic strokemicroglia

Identifiers

PMID41859393
PMCPMC12998461

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.