ArticleFrontiers in neurology2026
Cognitive dysfunction and hippocampal metabolic alterations in patients with postherpetic neuralgia.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Chronic pain is closely related to cognitive function, and pain caused by different etiologies may impair diverse domains of cognition. However, the change of cognitive function and cellular metabolism in hippocampus in postherpetic neuralgia (PHN) patients have received little attention. This study aimed to investigate the cognitive function and cellular metabolism changes in bilateral hippocampus in patients with PHN. Methods: From July 2021 to December 2024, 41 PHN patients, 48 acute herpes zoster (HZ) patients and 43 controls were enrolled. Results: Cognitive impairment occurred in 31.7% (13/41) of PHN patients, whose MoCA scores were significantly lower than HZ and control groups ( Conclusion: PHN patients have a high incidence of cognitive impairment, mainly characterized by reduced visualspatial execution, attention and abstraction abilities, they also exhibit metabolic changes in bilateral hippocampus. Among them, PHN patients with long duration of disease and severe pain have more significant changes. For the management of PHN patients, clinicians should not only pay attention to the patient's pain symptoms, but also to their cognitive and emotional disorders.
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