ArticleCureus2026
Natural Polyphenols Versus Standard Therapy: Effects on Neuroinflammation and Alpha-Synuclein Expression in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Mouse Model of Parkinson's Disease.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss, α-synuclein aggregation, and chronic neuroinflammation. While levodopa (L-DOPA) + carbidopa remains the cornerstone of symptomatic management, long-term use is associated with motor complications, prompting interest in adjunctive therapies targeting non-dopaminergic mechanisms. Polyphenolic compounds such as resveratrol and curcumin have demonstrated neuroprotective potential through antioxidant and anti-inflammatory actions. This study aimed to comparatively evaluate the effects of L-DOPA + carbidopa, resveratrol, curcumin, and their combination, resveratrol + curcumin, on motor function and biochemical markers in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Methodology An experimental study was conducted using 36 adult female C57BL/6 mice randomly allocated into six groups (
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