ArticleFrontiers in systems neuroscience2026
Dynamics of synchronous bursts in functionally coupled midbrain dopamine neurons driven by diverse excitatory inputs.
Article in Frontiers in systems neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Phasic dopamine (DA) release is related to reward processing and addiction. The prevailing view posits that this DA release originates from synchronous bursts of DA neuron groups, rather than individual neuron bursts. However, the mechanism by which diverse excitatory inputs synergistically induce synchronous bursts remains unclear. In biophysically realistic networks with complex structure, the responses of functionally connected DA neurons to various excitatory inputs are examined. Activating NMDA receptors alone results in asynchronous bursts, while co-activating with muscarinic receptors significantly enhances burst synchronization. The synchronization trends display qualitatively similar characteristics across all tested topological networks, indicating that these synchronous bursts are universal. Research on a dual-node network reveals that inhibitory couplings, specifically the inward rectifying K
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