Evidence map›Paper›PMID 41859644›Full record

ArticleMaterials today. Bio2026

An exosome-biomimetic photothermal nanocarrier for IGF2BP2 siRNA delivery and enhanced ferroptosis in head and neck squamous cell carcinoma.

Mengmeng Li, Die Hu, Congge Tan, Ou Peng, Qian Yang, Yekai Feng, Yuming Zhang, Yonghang Zhang, Bingbing Zhang, Lanjie Lei and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengmeng LiDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Die HuDepartment of Dermatology and Oral Medicine, First People's Hospital of Changde City, Changde, Hunan, 415000, China.
Congge TanDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, University of South China, Hengyang, 421001, China.
Ou PengDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Qian YangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Yekai FengDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Yuming ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Yonghang ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Bingbing ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Lanjie LeiKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Shisheng LiDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) commonly develops treatment resistance, highlighting the necessity of novel therapeutic strategies. Although ferroptosis has emerged as a promising route, its regulatory determinants and effective gene delivery approaches in HNSCC remain poorly understood. In this study, we determined that the RNA-binding protein IGF2BP2 promotes ferroptosis resistance in HNSCC, at least in part by associating with increased NRF2 mRNA stability and sustaining the NRF2-SLC7A11/GPX4 antioxidant axis. Actinomycin D chase assays further support an IGF2BP2-dependent post-transcriptional regulation of NRF2 under erastin-induced ferroptotic stress. To therapeutically target this pathway, we engineered a biomimetic hybrid nanocarrier (si@PLE) by fusing M1 macrophage-derived exosomes with photothermally responsive cationic liposomes for the targeted delivery of IGF2BP2 small interfering RNA (siRNA). si@PLE exhibited favorable physicochemical properties and stability, and exosome-liposome fusion improved siRNA protection and tumor accumulation compared with that of the matched non-fused control, enabling enhanced tumor-site heating under identical irradiation conditions. In vitro and in vivo, si@PLE combined with near-infrared laser irradiation enhanced ferroptosis relative to either monotherapy, significantly suppressing tumor growth with a favorable safety profile. Collectively, these findings establish a biomimetic gene silencing-photothermal platform to sensitize HNSCC to ferroptosis by targeting the IGF2BP2-NRF2 axis.

Indexed as

FerroptosisGene therapyHead and neck squamous cell carcinomaPhotothermal therapy

Identifiers

PMID41859644
PMCPMC12996677

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.