ArticleFrontiers in nutrition2026
Effects of functional dietary fiber supplementation combined with home-based exercise on gut microbiota diversity and low-grade inflammation in urban sedentary adults.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Gut microbiota-immune crosstalk in osteoarthritis: pathogenic mechanisms and emerging therapeutic opportunities.Frontiers in microbiology · 2026Review
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3 authors.
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Abstract
Introduction: Sedentary behavior is associated with gut microbiota dysbiosis and low-grade systemic inflammation, both of which contribute to increased cardiometabolic risk. However, the combined effects of functional dietary fiber supplementation and home-based exercise on these outcomes remain unclear. This study aimed to investigate whether a combined intervention could improve gut microbiota diversity and reduce systemic inflammation in urban sedentary adults. Methods: In this 24-week parallel-group randomized controlled trial, 140 sedentary adults were randomly assigned to an intervention group (functional dietary fiber supplementation providing 15-20 g/day of resistant starch, inulin, and beta-glucan combined with home-based moderate-intensity exercise, five sessions per week) or a control group maintaining their usual lifestyle. Gut microbiota diversity was assessed using 16S rRNA gene sequencing, and inflammatory markers (hs-CRP, IL-6, TNF-α, IL-10) were measured using immunoassays. Results: The intervention significantly increased gut microbiota alpha diversity, with Shannon index rising from 3.82 ± 0.48 to 4.31 ± 0.49 ( Conclusion: Combined functional dietary fiber supplementation and home-based exercise significantly improved gut microbiota diversity and reduced low-grade inflammation in sedentary adults. These findings support integrated lifestyle interventions as effective strategies for reducing cardiometabolic risk.
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