Evidence map›Paper›PMID 41859753›Full record

ReviewLancet regional health. Americas2026

Reframing computed tomography-associated cancer concerns in lifesaving screening: keeping the focus on lives saved.

Elochukwu Ezenwankwo, Daniel Nnate, Roger Y Kim, Jan M Eberth, Yeon Wook Kim

Abstract readReview
In one paragraph

Review in Lancet regional health. Americas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elochukwu EzenwankwoDrexel University Dornsife School of Public Health, Nesbitt Building, 3215 Market Street, Philadelphia, 19104, PA, USA.
Daniel NnateLung Cancer Screening Program, Liverpool Heart and Chest Hospital NHS Trust, UK.
Roger Y KimDivision of Pulmonary, Allergy and Critical Care, University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, 19104, PA, USA.
Jan M EberthDepartment of Population Health Sciences, Virginia Tech, 205 Duck Pond Drive, Blacksburg, VA, 24061, USA.
Yeon Wook KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, 13620, Republic of Korea.

Funding

Assessment of a Radiomics-Based Computer-Aided Diagnosis Tool for Cancer Risk Stratification of Pulmonary NodulesK08CA279881 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roger Yeon-Kyu Kim · 2023 to 2026
$998k
NCI NIH HHS K08 CA279881
6 · The paper itself

Abstract

Governments and health systems across the Americas are actively expanding access to lung cancer screening using low-dose computed tomography (LDCT). Our Viewpoint addresses renewed controversy surrounding cancer risks from CT radiation exposure, particularly in the context of LDCT lung cancer screening and early detection. While model-based projections of radiation-induced cancer risks offer useful insights, they risk overstating harm when divorced from real-world evidence of LDCT mortality benefit and safety profile, as well as from ongoing device and protocol refinements that have progressively reduced radiation exposure. Given the persistently low screening uptake and striking disparities in access among high-risk populations, overemphasis on projected risks may deter participation in the only validated screening intervention proven to reduce lung cancer mortality. We argue that the focus must remain on expanding access to high-quality LDCT screening and fostering clear, evidence-based communication that promotes informed decision-making, strengthens public trust, and advances health equity.

Indexed as

CT-associated cancer riskHigh-risk populationLow-dose computed tomographyLung cancer screening

Identifiers

PMID41859753
PMCPMC12997290

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.