ArticleUltrasonics sonochemistry2026
Ultrasound-assisted extraction of hypolipidemic actives from lotus (Nelumbo nucifera Gaertn.) seedpod: Process optimization, phytochemical characterization, and hypolipidemic activity.
Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lotus seedpod is a by-product of Lotus seed planting industry with abundant polyphenols. This study optimized the ultrasonic-assisted extraction (UAE) parameters of hypolipidemic compounds from lotus seedpod by response surface methodology guided-by lipase inhibition activity (LPIA). The major active compounds were enriched and identified, the in vitro and in vivo lipid lowering effect was explored by cell and mice models. The optimized conditions were 69% ethanol aqueous solution, ultrasonic power of 300 W and time of 62 min, under which the total polyphenol (TPC) and total flavonoid content (TFC) reached 125.41 mg GAE/g DM and 361.82 ± 2.76 mg QUE/g DM, respectively, with pancreatic lipase inhibitory activity (PLIA) of 8.38 ± 0.20 mg DM/mL. Ethyl acetate was the suitable solvent for enriching the hypolipidemic fraction in lotus seedpod polyphenol extract (LSPE). LSPE exhibited promising lipase inhibition (IC
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