Evidence map›Paper›PMID 41862204›Full record

Trial reportBMJ (Clinical research ed.)2026

Effect of a clinical decision support system on stroke care quality and outcomes in patients with acute ischaemic stroke (GOLDEN BRIDGE II): cluster randomised clinical trial.

Xinmiao Zhang, Lingling Ding, Jing Jing, Chunjuan Wang, Hongqiu Gu, Yong Jiang, Xia Meng, Tao Liu, Xuewei Xie, Man Xu and 24 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04524624 (A Multi-centre, Cluster Randomized Controlled Trial of an Artificial Intelligence-Based Clinical Decision Support System for Integrated Management of Patients With Acute Ischemic Stroke), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04524624 naunknown statusnot on this map

A Multi-centre, Cluster Randomized Controlled Trial of an Artificial Intelligence-Based Clinical Decision Support System for Integrated Management of Patients With Acute Ischemic Stroke: The GOLDEN BRIDGE II Trial

TypeinterventionalSponsorBeijing Tiantan HospitalRan2020 to 2023Enrolled21,689ConditionsStrokeArmsAI-based CDSS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Xinmiao ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Lingling DingDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Jing JingDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Chunjuan WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Hongqiu GuChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Yong JiangChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Xia MengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Tao LiuSchool of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Xuewei XieDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Man XuChina National Clinical Research Center-Hanalytics Artificial Intelligence Research Centre for Neurological Disorders, Beijing, China.
Meera HuChina National Clinical Research Center-Hanalytics Artificial Intelligence Research Centre for Neurological Disorders, Beijing, China.
Yanxu ZhangChina National Clinical Research Center-Hanalytics Artificial Intelligence Research Centre for Neurological Disorders, Beijing, China.
He FuChina National Clinical Research Center-Hanalytics Artificial Intelligence Research Centre for Neurological Disorders, Beijing, China.
Pan LiuChina National Clinical Research Center-Hanalytics Artificial Intelligence Research Centre for Neurological Disorders, Beijing, China.
Chunying DuChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Kejin DuChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Meng WangChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Hao LiChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Xiping GongDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Kehui DongDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Yunyun XiongDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Yilong WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Liping LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Zaihui ZhangDepartment of Neurology, Xiuyan Manchu Autonomous County Central People's Hospital, Anshan, China.
Yingzhuo ZangDepartment of Neurology, Qinghe People's Hospital, Xingtai, China.
Chunxiang YangDepartment of Neurology, Jingmen People's Hospital, Jingmen, China.
Ying XianDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Eric PetersonDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gregg C FonarowDivision of Cardiology, University of California, Los Angeles, CA, USA.
Lee H SchwammStrategy and Transformation, Yale School of Medicine, New Haven, CT, USA.
Xingquan ZhaoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
Zixiao LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.ORCID https://orcid.org/0000-0002-4713-5418
GOLDEN BRIDGE II Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of a clinical decision support system (CDSS) on stroke care quality and clinical outcomes among patients with acute ischaemic stroke.

designMulticentre, cluster randomised clinical trial.

setting77 hospitals across China.

participants77 hospitals (38 randomised to intervention group, 39 to control group) enrolled 21 603 patients with acute ischaemic stroke admitted to hospital within seven days after symptom onset.

interventionsHospitals in the intervention group received stroke CDSS support including artificial intelligence assisted imaging analysis, classification of stroke causes, and evidence based treatment recommendations. Hospitals in the control group provided usual care. MAIN OUTCOMES MEASURES: The primary outcome was a new vascular event (composite of ischaemic stroke, haemorrhagic stroke, myocardial infarction, and vascular death) within three months after initial symptom onset. Secondary outcomes included the composite measure and all-or-none measure of evidence based performance measures for acute ischaemic stroke care quality, a new vascular event at six and 12 months, and disability (modified Rankin Scale score 3-6) and all cause mortality at three, six, and 12 months. Safety outcomes were moderate or severe bleeding events and all bleeding events at three, six, and 12 months.

results11 054 patients in the intervention group and 10 549 patients in the control group were enrolled from January 2021 to June 2023. New vascular events at three months occurred in 2.9% (320/11 054) in the intervention group compared with 3.9% (416/10 549) in the control group (adjusted hazard ratio 0.74, 95% confidence interval (CI) 0.58 to 0.93, P=0.01). The CDSS intervention effect remained significant in the cluster level analysis (-0.01, -0.02 to -0.004, P=0.003). Patients in the intervention group were more likely to have a higher composite measure (91.4% (77 049/84 276)

conclusionsUse of the stroke CDSS in patients with acute ischaemic stroke in China led to a significant decrease in new vascular events at three months. The stroke CDSS intervention was also effective in improving stroke care quality and decreasing long term vascular events.

trial registrationClinicalTrials.gov NCT04524624.

Indexed as

Decision Support Systems, ClinicalIschemic StrokeQuality of Health CareAgedChinaFemaleHumansMaleMiddle AgedStrokeTreatment Outcome

Identifiers

PMID41862204
PMCPMC13003563

What Socratic holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.