ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
Repurposing Dexmedetomidine: Early Pharmacological Hypothermia Enhances Neuroprotection and Improves Locomotor and Bladder Functional Recovery after Spinal Cord Injury.
Aytak Khabbaz, Lilesh Kumar Pradhan, Anne Elizabeth Gowan, Samhita Chakraborty, Yihong Zhang, Fang Yuan, Eris Deanai Harris, Wei Li, Christopher Yu, Qigui Yu and 2 more
Abstract read
In one paragraphArticle in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Aytak KhabbazDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.ORCID 0000-0001-7758-0953 Lilesh Kumar PradhanDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Anne Elizabeth GowanDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Samhita ChakrabortyDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Yihong ZhangDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Fang YuanDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Eris Deanai HarrisDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Wei LiDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Christopher YuCollege of Arts and Sciences '28 Hutton Honors | Biology Major, Indiana University, Bloomington, Indiana 47405.ORCID 0009-0007-5614-2824 Qigui YuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.ORCID 0000-0002-3459-5634 Xiang GaoDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202 dengl@iu.edu xiangao@iu.edu.
Lingxiao DengDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202 dengl@iu.edu xiangao@iu.edu.ORCID 0000-0002-1293-8325 Funding
Plasticity of spinal L3 propriospinal neurons in urination recovery after thoracic SCIR21NS130241 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENG, LINGXIAO · 2022 to 2022
$436kNINDS NIH HHS R21 NS130241
6 · The paper itselfAbstract
Spinal cord injury (SCI) causes progressive secondary damage, yet translation of hypothermia, one of the few preclinical neuroprotectants, has been limited by slow, equipment-dependent cooling that rarely meets the therapeutic window. We tested whether repurposing dexmedetomidine (Dex), an FDA-approved α
Indexed as
DexmedetomidineDrug RepositioningHypothermia, InducedLocomotionNeuroprotective AgentsRecovery of FunctionSpinal Cord InjuriesUrinary BladderAnimalsFemaleMaleMiceMice, Inbred C57BLDexmedetomidineNeuroprotective Agentsanti-inflammationbladder functionlocomotorpharmacological hypothermia
Identifiers
PMID41862205
PMCPMC13108387
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390