ArticleCommunications medicine2026
Assessment of genetic susceptibility in patients with oral squamous cell carcinoma: a systematic review and meta-analysis.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundOral squamous cell carcinoma (OSCC) is associated with many risk factors but not all individuals who are exposed to the risk factors develop OSCC. This aspect warrants the need to understand the genetic susceptibility in presence of risk factors.
methodsThe study protocol has been registered with PROSPERO (CRD42023422519). The present study included the English-language literature published from January 2000 to April 2024. The articles were searched using keywords via Ovid platform through various databases. The odds ratio was considered as standard measure of outcome. Meta-analysis was carried out using random effects model with RevMan 5.4, establishing a 95% confidence interval and a significance threshold of p ≤ 0.05.
resultsTaiwan, China, India, and USA share the major bulk of studies. The subgroup analysis shows polymorphism in P53 gene in presence of smoking (Z = 2.15, p = 0.02), alcohol (Z = 2.38, p = 0.02) and mixed habit (tobacco + alcohol) (Z = 3.28, p ≤ 0.001) and CASP 8 (Z = 5.38, p ≤ 0.0001) in presence of alcohol consumption habit has highly significant risk for development of OSCC; however the studies shows moderate heterogeneity (I
conclusionsAsian countries show a large cluster of patients with a genetic risk for development of OSCC. Genetic factors such as P53, CASP 8, HIF, DEC1, MTNR1 and CYP1A1 show statistically significant risk for development of OSCC in the presence of risky environmental factors such as tobacco and alcohol.
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