Evidence map›Paper›PMID 41862535›Full record

ArticleScientific reports2026

Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform.

Maqsood Ali, Roberto Smiriglia, Emiliano Spera, Safeer A Mirani, Sergio M G Solinas, Michele Migliore, Giorgio A Ascoli, Luca L Bologna

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maqsood AliSchool of Advanced Studies, Center for Neuroscience, University of Camerino, Camerino, Italy. ali.maqsood@ibf.cnr.it.
Roberto SmirigliaInstitute of Biophysics, National Research Council, Palermo, Italy.
Emiliano SperaInstitute of Biophysics, National Research Council, Palermo, Italy.
Safeer A MiraniDepartment of Life Sciences and Biotechnologies, University of Sassari (UNISS), Sassari, Italy.
Sergio M G SolinasDepartment of Life Sciences and Biotechnologies, University of Sassari (UNISS), Sassari, Italy.
Michele MiglioreInstitute of Biophysics, National Research Council, Palermo, Italy.
Giorgio A AscoliBioengineering Department, Center for Neural Informatics, Structure, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, 22030, USA.
Luca L BolognaInstitute of Biophysics, National Research Council, Palermo, Italy.

Funding

Generation and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9M
HORIZON EUROPE Framework Programme 101147319 (EBRAINS2.0)Ministero dell'Università e della Ricerca 20228RMXBE (HIPPOCOMP)Ministero dell'Università e della Ricerca 2022JE5SK2 (FeNeL)NextGenerationEU IR0000011 (EBRAINS-Italy)NIH HHS R0139600NINDS NIH HHS R01 NS039600
6 · The paper itself

Abstract

Brain modeling has emerged as a fundamental tool for understanding neural mechanisms and information processing across different spatial and temporal scales. However, the simulation and visualization of realistic full-scale neural models remain a challenge. To address this, we developed the Neural Circuit Visualizer (NCV), a web-based platform for the flexible simulation and visualization of full-scale point-neuron circuits. We integrated state-of-the-art scientific advances, such as region-specific connectivity and the anatomical reconstruction of the mouse right hippocampal CA1 region, with resources and services from mature research infrastructures (e.g., Hippocampome.org, ebrains.eu, ebrains-italy.eu) and high-performance computing (HPC) facilities. The resulting online tool provides a public resource for the simulation and visualization of neural dynamics in full-scale point-neuron models and fosters the comprehension of neural mechanisms under physiological and pathological conditions. The tool is released as open source to encourage further collaborative development and integration.

Indexed as

Computer SimulationModels, NeurologicalNerve NetNeuronsSoftwareAnimalsInternetMice

Identifiers

PMID41862535
PMCPMC13144725

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.