Evidence map›Paper›PMID 41862616›Full record

ArticleNature plants2026

TaHST2 silencing shapes basal heat tolerance in allohexaploid wheat.

Runqi Zhang, Guoyu Liu, Shanshan Zhai, Xinhao Meng, Jiazheng Yu, Yuqi Zhang, Shidian Wen, Xinghua Luo, Wenxuan Han, Hongyao Lou and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Runqi Zhang *State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0001-7383-416X
Guoyu Liu *State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Shanshan ZhaiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Xinhao MengState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Jiazheng YuState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Yuqi ZhangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Shidian WenState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Xinghua LuoState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Wenxuan HanState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Hongyao LouBeijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Tianjiao ShaoState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Rongqi LiangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-8423-7341
Jun MaState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-7566-4317
Huijie ZhaiSchool of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang, China.
Mingshan YouState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Chaojie XieState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0001-6955-3330
Yufeng ZhangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.
Jie LiuState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-1415-3847
Zhaorong HuState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-1815-648X
Weilong GuoState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0001-5199-1359
Qixin SunState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-3819-6892
Jiewen XingState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China. jiewen.xing@cau.edu.cn.ORCID http://orcid.org/0000-0003-3503-0739
Zhongfu NiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China. nizf@cau.edu.cn.ORCID http://orcid.org/0000-0003-4524-7720
Baoyun LiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, China Agricultural University, Beijing, China. baoyunli@cau.edu.cn.ORCID http://orcid.org/0000-0002-6794-1150

Funding

China Postdoctoral Science Foundation 2023M743818; GZC20233050National Natural Science Foundation of China (National Science Foundation of China) 32372210National Natural Science Foundation of China (National Science Foundation of China) 32401832National Natural Science Foundation of China (National Science Foundation of China) 32530075
6 · The paper itself

Abstract

Global warming poses a substantial threat to crop productivity, yet the genetic basis of thermotolerance in wheat remains poorly understood. Here we cloned a heat stress tolerance (HST) gene, TaHST2, and revealed that it underwent functional silencing during wheat domestication. As a negative regulator of basal HST, TaHST2 was progressively suppressed through intronic sequence polymorphisms and epigenetic modifications, which might be an evolutionary consequence of hexaploidization. Haplotype analysis suggests strong artificial selection against TaHST2 expression, favouring improved thermotolerance in cultivated wheat. Further studies demonstrated that TaHST2 encodes a ubiquitin hydrolase that stabilizes HST repression proteins TaHSC701 and TaHSC702, thereby modulating heat response pathways. Our findings uncover a potential key genetic event in wheat evolution and offer new strategies for utilizing synthetic hexaploidy and octoploid wheat to breed heat-resilient varieties.

Indexed as

Plant ProteinsThermotoleranceTriticumGene Expression Regulation, PlantGene SilencingHeat-Shock ResponseHot TemperaturePolyploidyPlant Proteins

Identifiers

PMID41862616

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.