Evidence map›Paper›PMID 41862629›Full record

ArticleCommunications biology2026

Ontogeny independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis.

Shoumit Dey, Jian-Hua Cao, Benjamin Balluff, Gaia Mazza, Helen Ashwin, Lesley Gilbert, Sally James, Adam A Dowle, Grant Calder, Nidhi Sharma Dey and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shoumit Dey *York Biomedical Research Institute, Hull York Medical School, University of York, York, UK.ORCID http://orcid.org/0000-0003-2655-9921
Jian-Hua Cao *Maastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, the Netherlands.
Benjamin BalluffMaastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0003-0351-240X
Gaia MazzaYork Biomedical Research Institute, Hull York Medical School, University of York, York, UK.ORCID http://orcid.org/0009-0005-8796-0278
Helen AshwinYork Biomedical Research Institute, Hull York Medical School, University of York, York, UK.ORCID http://orcid.org/0000-0003-1029-0032
Lesley GilbertBiosciences Technology Facility, Department of Biology, University of York, York, UK.
Sally JamesBiosciences Technology Facility, Department of Biology, University of York, York, UK.ORCID http://orcid.org/0000-0003-2701-9724
Adam A DowleBiosciences Technology Facility, Department of Biology, University of York, York, UK.ORCID http://orcid.org/0000-0002-6501-5444
Grant CalderBiosciences Technology Facility, Department of Biology, University of York, York, UK.
Nidhi Sharma DeyYork Biomedical Research Institute, Hull York Medical School, University of York, York, UK.ORCID http://orcid.org/0000-0001-9432-0221
Peter O'TooleBiosciences Technology Facility, Department of Biology, University of York, York, UK.ORCID http://orcid.org/0000-0001-5295-2001
Ron M A HeerenMaastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, the Netherlands. r.heeren@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-6533-7179
Paul M KayeYork Biomedical Research Institute, Hull York Medical School, University of York, York, UK. paul.kaye@york.ac.uk.ORCID http://orcid.org/0000-0002-8796-4755

Funding

RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/K039660/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/M028127/1Wellcome Trust (Wellcome) WT224290
6 · The paper itself

Abstract

Granulomas are organized inflammatory lesions formed in response to persistent stimuli such as infections. Murine infection with Leishmania donovani results in granulomas in the liver, seeded by infected Kupffer cells, and serves as a well-defined model of infection-induced granuloma formation. The resolution of granulomatous inflammation requires dynamic shifts in immune-cell activation states, imposing metabolic demands. As mediators of cell signaling, lipid metabolism plays a key role in regulating inflammation and infection. How lipid changes are spatially linked to altered immune cell transcription remains unresolved. We performed a multimodal imaging analysis combining MALDI mass spectrometry, spatial and single cell transcriptomics, proteomics of flow-sorted macrophages and histopathology of L. donovani induced hepatic granulomas. Using this spatially-integrated approach, we identified LPCAT2-mediated membrane re-modelling of myeloid cells as a novel feature of these granulomas. Our study provides new insights into local immunometabolic changes associated with granuloma formation and macrophage activation.

Indexed as

GranulomaLeishmania donovaniLeishmaniasis, VisceralMacrophagesAnimalsFemaleLiverMacrophage ActivationMiceMice, Inbred C57BL

Identifiers

PMID41862629
PMCPMC13168283

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.