Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Effectiveness of oral mucositis management based on MASCC/ISOO guidelines in pediatric oncology patients: a randomized controlled trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06711315 (Oral Mucositis Management Supported by MASCC/ISOO Protocols), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Oral Mucositis Management Supported by MASCC/ISOO Protocols: A Randomized Controlled Trial in Pediatric Oncology Patients
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough survival rates in childhood cancer have improved with more effective, risk-adapted multimodal treatments, oral mucositis remains one of the most common treatment-related oral complications. This study evaluated the impact of an oral mucositis care protocol on the severity of mucositis.
methodsThis prospective randomized controlled study was conducted with 30 pediatric oncology patients aged 6 to 18 years. The sample included children with hematologic malignancies (predominantly acute lymphoblastic leukemia) and solid tumors. The data were collected using a descriptive information form, the Children's International Mucositis Evaluation Scale (ChIMES), and the WHO Oral Mucositis Grading Scale. Standard care was applied to the control group. For the intervention group, an oral care protocol was prepared, and the patients received training. The oral care intervention was applied for 14 days and monitored by the researcher. The patients were monitored for oral mucositis on Days 0, 3, 7, and 14. Those in the intervention group received a calendar for documenting their oral care practices.
resultsThe ChIMES scores showed a significant difference between the groups and were lower in the intervention group (z = 0.010; p = 0.011). The WHO scale results revealed significant differences between the groups on Day 7 (Z = -3.106; p = 0.002) and Day 14 (Z = -2.841; p = 0.005).
conclusionAt the end of the study, the severity of mucositis was lower in the patients who received the oral mucositis care protocol. It is recommended that a standardized oral care protocol specific to children be developed and that education on oral mucositis care be provided to children and their parents from the beginning of hospitalization. CLINICAL
trial registrationClinicalTrials.gov (Identifier: NCT06711315; Registration date: 29 November 2024).
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