SynthesisDigestive diseases and sciences2026
Efficacy of Olezarsen in Severe Hypertriglyceridemia and Acute Pancreatitis Risk: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Synthesis in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOlezarsen has shown efficacy in hypertriglyceridemic and dyslipidemic populations of mixed cohorts, but its effectiveness in severe hypertriglyceridemia(SHTG) is unknown. This is a systematic review and meta-analysis to evaluate the efficacy of olezarsen in SHTG and the associated risk of pancreatitis.
methodPubMed, Embase, and Cochrane databases were systematically searched for published trials comparing olezarsen vs placebo in SHTG patients up to December 03, 2025. We computed mean difference (MD) and risk ratio (RR) with 95% CI for continuous and binary endpoints, respectively, using a random-effects model. Significance level was set with P-value (< 0.05).
resultsFrom 228 database records, three randomized trials involving 1127 patients were included, with a 12-month follow-up. Of these, 748 patients (66.3%) received olezarsen. Olezarsen significantly reduced the mean percentage change from baseline of triglyceride (TG) levels, especially for the non-familial chylomicronemia syndrome(non-FCS) population (MD = - 59.95%; 95% CI - 76.00 to - 43.90; P = .001), of apolipoprotein C-III levels (MD = - 66.68%; 95% CI - 80.86 to - 52.69; P = .0006) at 6 months compared to placebo, albeit with significant heterogeneity. Significant reductions were also observed for other lipid parameters, specifically Non-high-density lipoprotein cholesterol (non-HDL-C) (MD = - 23.72%; 95% CI: - 27.35, - 20.09; P = .00001) and Remnant cholesterol(RC) (MD = - 55.30%;95% CI: - 62.05, -48.56; P = .00001) with an increase in LDL level. Olezarsen reduced the risk of acute pancreatitis (1.2% vs 8.7%; RR = 0.14; 95% CI: 0.07, 0.29; P = .00001) compared to placebo. No significant adverse events were observed between groups.
conclusionOur analysis suggests olezarsen may be an effective therapeutic option in SHTG for reducing lipids and acute pancreatitis risk. However, its long-term safety and efficacy remain to be explored in future trials in this cohort.
Indexed as
Identifiers
41865223What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.