ArticleBiogerontology2026
Epigallocatechin gallate mitigates oxidative stress-induced transient senescence and injury by preserving mitochondrial integrity and restoring redox-inflammatory homeostasis in murine macrophages.
Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Macrophages serve as major defenders against pathogens, playing a crucial role in the initiation and modulation of immune responses. Age-related decline in macrophage functions is attributed to a complex network of cellular senescence and immunosenescence. The onset of cellular senescence is often a consequence of sustained oxidative stress, which is worsened by immunosenescence. Green tea catechin, epigallocatechin gallate (EGCG), has emerged as a promising candidate for promoting healthy aging by reducing cellular senescence and enhancing cytoprotective responses. However, its effectiveness in preventing oxidative stress-induced senescence and dysfunction in immune cells, particularly macrophages, remains less characterized. The present study explored the anti-senescence and cytoprotective effects of EGCG in the wake of oxidative stress-induced premature senescence in RAW 264.7 macrophages. Oxidative stress was induced in cells using repeated exposure to hydrogen peroxide (H
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