Evidence map›Paper›PMID 41865369›Full record

ArticleCell reports2026

Gene regulatory network determinants of rapid recall in human memory CD4

Alexander Katko, Svetlana Korinfskaya, Anthony T Bejjani, Seyifunmi M Owoeye, Zi F Yang, Akshata N Rudrapatna, Sarah Potter, Joseph A Wayman, Michael Kotliar, Leah C Kottyan and 2 more

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alexander KatkoDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Svetlana KorinfskayaDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Anthony T BejjaniDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Seyifunmi M OwoeyeDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Zi F YangDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Akshata N RudrapatnaDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Sarah PotterDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Joseph A WaymanDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Michael KotliarDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Leah C KottyanDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Artem BarskiDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: artem.barski@ccchmc.org.
Emily R MiraldiDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: emily.miraldi@cchmc.org.

Funding

Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
Dynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8M
An experimentally-refined, dynamic gene regulatory network model of T-cell memoryR01AI153442 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI BARSKI, ARTEM, MIRALDI, EMILY · 2021 to 2025
$3.2M
Gene regulatory network modeling of disease-associated DNA methylation perturbationsR01AI173314 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Minji Byun, Emily Miraldi · 2023 to 2026
$3.1M
SciDAP: Scientific Data Analysis PlatformR42HG011219 · NHGRI · DATIRIUM, LLC · PI BARSKI, ARTEM, KARTASHOV, ANDREY · 2022 to 2023
$1.6M
NHGRI NIH HHS R42 HG011219NIAID NIH HHS R01 AI153442NIAID NIH HHS R01 AI173314NIAID NIH HHS U01 AI150748NIAMS NIH HHS P30 AR070549
6 · The paper itself

Abstract

Rapid recall is the hallmark of memory T cells. While naive cells require days to mount effector responses to new threats, antigen-experienced memory cells produce cytokines within hours of a repeat encounter. Compared to naive cells, memory cells exhibit enhanced chromatin accessibility proximal to rapid-recall genes, but the transcription factors (TFs) that establish, maintain, and utilize these putative regulatory elements are unknown. We leverage single-nuclei multiome sequencing (gene expression and chromatin accessibility) to characterize the dynamic activation responses of CD4

Indexed as

chromatin accessibilityCP: immunologyepigeneticsgene regulatory networkhuman CD4 T cell memorymultiome-seqrapid recallsingle-cell genomicstranscription factor

Identifiers

PMID41865369
PMCPMC13207208

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.