Evidence map›Paper›PMID 41866449›Full record

ReviewNeuroscience bulletin2026

Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms.

Zihui Wang, Feifei He, Lingzhi Li, Wei Wang, Lisan Zhang, Jinsong Tang, Weidong Le

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zihui WangDepartment of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, China.ORCID http://orcid.org/0000-0003-1712-2293
Feifei HeKey Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116000, China.ORCID http://orcid.org/0009-0002-2434-6826
Lingzhi LiDepartment of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, China.ORCID http://orcid.org/0000-0002-4308-0659
Wei WangDepartment of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, China.ORCID http://orcid.org/0000-0003-2302-6273
Lisan ZhangDepartment of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, China.ORCID http://orcid.org/0000-0002-3774-9926
Jinsong TangDepartment of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. tangjinsong@zju.edu.cn.ORCID http://orcid.org/0000-0003-3796-1377
Weidong LeDepartment of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, China. wdle@sibs.ac.cn.ORCID http://orcid.org/0000-0001-7459-2705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), multiple system atrophy (MSA), amyotrophic lateral sclerosis (ALS), and others, represent an escalating public health burden in aging populations. NDDs are characterized by progressive neuronal loss and misfolded protein aggregation. Despite distinct clinical heterogeneity, these diseases universally present with debilitating non-motor symptoms, among which sleep-wake disorders are highly prevalent. Once considered secondary to neuronal damage, growing evidence now highlights a bidirectional interplay: sleep disruption is not only a consequence of neurodegeneration but also exacerbates its progression. This review synthesizes this complex interplay, outlining sleep phenotypes across major NDDs, dissecting key underlying mechanisms (impaired protein homeostasis, glymphatic dysfunction, chronic neuroinflammation, sleep-regulatory nucleus vulnerability, and circadian dysregulation), and summarizing current pharmacotherapeutic and non-pharmacological interventions. Attenuating sleep disorders may therefore provide symptomatic relief and disease‑modifying effects for NDDs.

Indexed as

Glymphatic systemNeurodegenerative diseasesNeuroinflammationREM sleep behavior disorderSleep disorders

Identifiers

PMID41866449

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.