Trial reportChiropractic & manual therapies2026
Mobilization with movement enhances early rehabilitation outcomes in knee osteoarthritis: a six-week randomized controlled trial.
Trial report in Chiropractic & manual therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05577403 (Effect of Mulligan's Mobilization With Movement Added With Isometric Exercises on Muscle Strength Pain and Disability Associated With Knee Osteoarthritis), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Mulligan's Mobilization With Movement Added With Isometric Exercises on Muscle Strength Pain and Disability Associated With Knee Osteoarthritis: A Randomized Controlled Study
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundExercise is a first-line approach for knee osteoarthritis (KOA), yet pain during movement may limit adherence. Mulligan’s mobilization with movement (MWM) is proposed to facilitate pain-free exercise and hasten early clinical gains.
objectiveTo determine whether adding MWM to isometric training (IT) improves pain, quadriceps strength, and disability over six weeks compared with IT alone.
methodsTwo-arm, double-masked RCT in adults with radiographic KOA (Kellgren–Lawrence grade 2–3). Participants were randomized to MWM + IT or IT-only (n = 25/group), 5 supervised sessions/week for 6 weeks. Outcomes: pain (VAS), quadriceps strength (strain-gauge dynamometry), disability (WOMAC) measured at baseline, weeks 1, 3, and 6. Primary analyses used linear mixed-effects models with fixed effects for Group, Time, and Group × Time and a random intercept for Subject; joint Wald tests evaluated factor significance.
resultsSignificant Time effects indicated improvement across outcomes (VAS χ2(3) = 456.338, p < 0.0001; STN χ2(3) = 186.876, p < 0.0001; WOMAC χ2(3) = 1515.459, p < 0.0001). Group×Time interactions were significant for VAS (χ2(3) = 170.550, p < 0.0001), STN (χ2(3) = 204.327, p < 0.0001), and WOMAC (χ2(3) = 71.041, p < 0.0001), demonstrating faster and larger six-week gains with MWM + IT. The Group main effect was significant for VAS (χ2(1) = 42.599, p < 0.0001) and non-significant for STN (χ2(1) = 0.613, p = 0.4336) and WOMAC (χ2(1) = 0.019, p = 0.8901).
conclusionAdding MWM to IT accelerated and amplified six-week improvements in pain, strength, and function compared with IT alone. Early integration of MWM may enhance pain-free exercise and short-term rehabilitation outcomes in KOA. Larger multicentre trials with extended follow-up and economic evaluation are warranted.
trial registrationClinicalTrials.gov Identifier: NCT05577403; prospectively registered on 12 /07/2021 (last updated on 14/09/2025).; available at https://clinicaltrials.gov/study/NCT05577403 .
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