ArticlemedRxiv : the preprint server for health sciences2026
Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.
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Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
130 authors.
Heming WangDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-1486-7495
Pavithra NagarajanDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0036-9970
Clint L MillerDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Raymond NoordamDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Kenneth E WestermanDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7619-1868
Michael R BrownDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Aldi T KrajaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Karen SchwanderDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Changwei LiDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center.
Mihir M SanghviCentre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.
Yipei SongDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Vincent Braunack-MayerDiabetes Center Berne, Bern, BE, Switzerland.
Ling ChenMassachusetts General Hospital, Boston, MA,USA.
Jiawen DuDepartment of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-3711-8101
Diana DuncaCentre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0933-2410
Valborg GudmundsdottirIcelandic Heart Association, Kopavogur, Iceland.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4941-5106
Heather M HighlandDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zhijie HuangDepartment of Epidemiology, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, LA, US.
Changhoon KangGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Timo A LakkaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Christophe LefevreSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Celestin MissikpodeDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
John L MorrisonDivision of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anne RichmondCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Mina ShahisavandiDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Jingxian TangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Chenglong YuSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Wanying ZhuDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Md Abu Yusuf AnsariDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Pramod AnuguJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Hugues AschardDepartment of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-7554-6783
Kaavya AshokBroad Institute, Cambridge, MA, USA.
John R AttiaSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID 0000-0001-9800-1308
Lydia A BazzanoDepartment of Epidemiology, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, LA, US.ORCID 0000-0002-8958-1352
Brian E CadeDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1424-0673
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Latchezar M DimitrovDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anh DoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Tariq FaquihDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-8026-2251
Sandy L FinesilverSmithCentre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.
Susan P Fisher-HochDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Amanda M FrettsCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.
Sina A GharibDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mariaelisa GraffDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Charles GuCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8527-8145
Paul HansonMassachusetts General Hospital, Boston, MA,USA.
Jiang HeDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
James HixsonDepartment of Epidemiology, School of Public Health, UTHealth Houston, Houston, TX, USA.
Sarah HsuMassachusetts General Hospital, Boston, MA,USA.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Minjung KhoGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Hyunju KimCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD, USA.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Lifelines Cohort Study
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Joseph B McCormickDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7892-193X
Olli T RaitakariCentre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, InFLAMES Research Flagship, Turku University Hospital and University of Turku, Turku, Finland.
Julia RamírezCentre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.
Renata L RihaDepartment of Sleep Medicine, The University of Edinburgh, Edinburgh, UK.
Martin RischCentral Laboratory, Cantonal Hospital Graubünden, Chur, Switzerland.
Lorenz RischFaculty of Medical Sciences, Institute for Laboratory Medicine, Private University in the Principality of Liechtenstein, Triesen, Liechtenstein.
Tom C RussAlzheimer Scotland Dementia Research Centre, Department of Psychology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9797-2188
Chloé SarnowskiDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.ORCID 0000-0002-6090-7099
Miranda T SchramDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Tamar SoferCardioVascular Institute (CVI), Beth Israel Deaconness Medical Center, Boston, MA, USA.ORCID 0000-0001-8520-8860
Quan SunDepartment of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-8324-2803
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Yujie WangDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ko Willems van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Alexis C WoodUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Kristin L YoungDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ruiyuan ZhangDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Jennifer E BelowVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
David ConenPopulation Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Simon R CoxLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Ervin R FoxDivision of Cardiovascular Disease, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Nora FranceschiniDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0002-9476-7143
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Caroline HaywardCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Elizabeth G HollidaySchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Cashell E JaquishDivision of Cardiovascular Science, Epidemiology Branch, NHLBI, NIH, Bethesda, Maryland, USA.
Paul LacazeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.ORCID 0000-0002-0902-6798
Seunggeun LeeGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-2555-4427
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-0703-0742
Alanna C MorrisonDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Kari E NorthDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Lynne E WagenknechtDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Ayush GiriDivision of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Tanika N KellyDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Patricia B MunroeCentre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-4176-2947
James GaudermanDivision of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.ORCID 0000-0003-0292-5421
Paul S de VriesDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Dabeeru C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Alisa K ManningMassachusetts General Hospital, Boston, MA,USA.
Han ChenDepartment of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.ORCID 0000-0002-9510-4923
Lisa de Las FuentesCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
James B MeigsProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both short and long sleep duration have been associated with poor glycemic control and an increased risk of developing type 2 diabetes mellitus. Although sleep duration may differentially modify the effects of genetic risk factors for type 2 diabetes, this has not been systematically investigated. In the present study, we conducted genome-wide gene by sleep duration meta-analyses, separately assessing interactions of short and long sleep, for fasting glucose, fasting insulin, and hemoglobin A1c in up to 489,309 individuals without diabetes from seven different population groups. In total, 16 loci were identified to interact with sleep duration - six with short sleep and ten with long sleep. Of these, four loci were identified through cross-population meta-analysis. Mapped genes exhibit pathway connections to pericyte apoptosis, NMDA receptor activity, the GLUT1 receptor, neurological health, and sleep architecture. Eleven loci (
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