Evidence mapPaperPMID 41867206Full record

ArticlemedRxiv : the preprint server for health sciences2026

Automated machine learning of echocardiographic strain enables identification of early myocardial changes in pre-symptomatic TTR carriers.

Amit Weigman, Wenli Zhao, Steve L Liao, Maria Giovanna Trivieri, Samuel Madiman, Stamatios Lerakis, Eimear E Kenny, Noura S Abul-Husn, Vikas Pejaver, Amy R Kontorovich

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amit WeigmanIcahn School of Medicine at Mount Sinai, New York, NY.
Wenli ZhaoFuster Heart Hospital, New York, NY.
Steve L LiaoFuster Heart Hospital, New York, NY.
Maria Giovanna TrivieriFuster Heart Hospital, New York, NY.ORCID 0000-0001-6601-3267
Samuel MadimanFuster Heart Hospital, New York, NY.
Stamatios LerakisFuster Heart Hospital, New York, NY.
Eimear E KennyThe Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-9198-759X
Noura S Abul-HusnThe Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-5179-1944
Vikas PejaverThe Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-1943-0284
Amy R KontorovichFuster Heart Hospital, New York, NY.ORCID 0000-0001-7400-5507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To identify unique echocardiographic signatures associated with Background: Carrier status for the most common pathogenic Methods: V142I+ carriers (cases) without prior diagnoses of amyloidosis or HF were identified among Bio Results: 49 Conclusions: Machine learning applied to routinely acquired echocardiographic data can identify subtle myocardial abnormalities associated with

Indexed as

cardiac amyloidosisgeneticsmachine learningspeckle tracking echocardiographyTTR

Identifiers

PMID41867206
PMCPMC13004165

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.