Evidence map›Paper›PMID 41867230›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Cancer genomic profiling predicts pathogenicity of

Olga Kondrashova, Rebecca L Johnston, Michael T Parsons, Aimee L Davidson, Daffodil M Canson, Khoa A Tran, Melissa S Cline, Nicola Waddell, Smruthy Sivakumar, Ethan S Sokol and 5 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Olga KondrashovaCancer Research Program, QIMR Berghofer, Brisbane, Australia.ORCID 0000-0003-0022-5149
Rebecca L JohnstonCancer Research Program, QIMR Berghofer, Brisbane, Australia.
Michael T ParsonsPopulation Health Program, QIMR Berghofer, Brisbane, Australia.ORCID 0000-0003-3242-8477
Aimee L DavidsonPopulation Health Program, QIMR Berghofer, Brisbane, Australia.
Daffodil M CansonPopulation Health Program, QIMR Berghofer, Brisbane, Australia.
Khoa A TranCancer Research Program, QIMR Berghofer, Brisbane, Australia.ORCID 0000-0001-7376-5061
Melissa S ClineUC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, United States.
Nicola WaddellCancer Research Program, QIMR Berghofer, Brisbane, Australia.
Smruthy SivakumarFoundation Medicine Inc., Boston, MA, United States.
Ethan S SokolFoundation Medicine Inc., Boston, MA, United States.
Dexter X JinFoundation Medicine Inc., Boston, MA, United States.
Dean C PavlickFoundation Medicine Inc., Boston, MA, United States.
Brennan DeckerFoundation Medicine Inc., Boston, MA, United States.
Garrett M FramptonFoundation Medicine Inc., Boston, MA, United States.
Amanda B SpurdlePopulation Health Program, QIMR Berghofer, Brisbane, Australia.

Funding

Upgrading rigor and efficiency of germline cancer gene variant classification for the 2020sR01CA264971 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Sean Vahram Tavtigian · 2022 to 2026
$2.9M
Curation Expert Panels for BRCA1/2 and Hereditary Breast, Ovarian and Pancreatic (HBOP) Cancer GenesU24CA258058 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2022 to 2026
$1.3M
NCI NIH HHS R01 CA264971NCI NIH HHS U24 CA258058
6 · The paper itself

Abstract

Accurate classification of

Indexed as

BRCA1BRCA2cancercancer genomic profilingHRDmachine learningvariant classificationVUS

Identifiers

PMID41867230
PMCPMC13004087

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.