Evidence map›Paper›PMID 41867449›Full record

ArticleJournal of inflammation research2026

Elevated Serum IL-6/IL-10 Ratio as a Promising Diagnostic and Disease Grading Biomarker for Cerebral Small Vessel Disease.

Lei Li, Yang Chen, Guojun He, Yang Gao, Yongqing Cheng, Jin Chen, Dingming Sun, Mingyu Shi

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Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lei LiDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.
Yang ChenDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.
Guojun HeDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.
Yang GaoDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.
Yongqing ChengDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.
Jin ChenDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.
Dingming SunDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.
Mingyu ShiDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224005, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic inflammation and the imbalance of M1/M2 phenotype of microglia contribute to the onset and progression of cerebral small vessel disease (CSVD). Currently, no effective biomarkers for diagnosing CSVD are found. Our research aims to explore the efficacy of IL-6/IL-10 ratio in the diagnosis of CSVD and assessment of its severity, establishing IL-6/IL-10 as an independent predictive biomarker. Patients and Methods: A total of 155 participants admitted to the First People's Hospital of Yancheng City from February 2022 to September 2024 were grouped based on MRI and CSVD imaging scoring. Clinical and laboratory data were collected and analyzed. Results: Compared with the healthy control group, the CSVD group showed significant increases of IL-6/IL-10 ratio in peripheral blood ( Conclusion: IL-6/IL-10 ratio is a potential circulating biomarker for diagnosing CSVD, with good diagnostic efficacy and has the ability to distinguish the severity of the disease to a certain degree.

Indexed as

biomarkercerebral small vessel diseaseIL-6/IL-10microglia polarizationneuroinflammation

Identifiers

PMID41867449
PMCPMC13003666

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.