Evidence map›Paper›PMID 41867642›Full record

ArticleSovremennye tekhnologii v meditsine2026

TEM-based Study of the Phenotype of Astrocytes Differentiated from Induced Pluripotent Stem Cells from a Healthy Donor and a Patient with Parkinson's Disease.

K A Kutukova, M V Ivanov, E V Novosadova, A V Brydun, E L Arsenyeva, L V Novosadova, I V Kokorev, I A Grivennikov, V S Sukhorukov, S N Illarioshkin

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In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

K A KutukovaJunior Researcher, Laboratory of Neuromorphology, Institute of Brain Research; Russian Research Center of Neurology and Neurosciences, 80 Volokolamskoye Shosse, Moscow, 125367, Russia; Senior Lecturer, Department of Morphology, Institute of Anatomy and Morphology; Pirogov Russian National Research Medical University, 1 Bldg., 6 Ostrovityanova St., Moscow, 117513, Russia.
M V IvanovJunior Researcher, Laboratory of Neuromorphology, Institute of Brain Research; Russian Research Center of Neurology and Neurosciences, 80 Volokolamskoye Shosse, Moscow, 125367, Russia; Senior Lecturer, Department of Morphology, Institute of Anatomy and Morphology; Pirogov Russian National Research Medical University, 1 Bldg., 6 Ostrovityanova St., Moscow, 117513, Russia.
E V NovosadovaPhD, Senior Researcher, Laboratory of Cell Differentiation; National Research Center "Kurchatov Institute", 1 Academician Kurchatov Square, Moscow, 123182, Russia; Leading Researcher, Laboratory of Translational Biomedicine; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1a Malaya Pirogovskaya St., Moscow, 119435, Russia.
A V BrydunMD, PhD, Researcher; Russian Research Center of Neurology and Neurosciences, 80 Volokolamskoye Shosse, Moscow, 125367, Russia; Head of the Educational Laboratory, Department of Morphology, Institute of Anatomy and Morphology; Pirogov Russian National Research Medical University, 1 Bldg., 6 Ostrovityanova St., Moscow, 117513, Russia.
E L ArsenyevaPhD, Chief Specialist; National Research Center "Kurchatov Institute", 1 Academician Kurchatov Square, Moscow, 123182, Russia.
L V NovosadovaEngineer, Grade 1; National Research Center "Kurchatov Institute", 1 Academician Kurchatov Square, Moscow, 123182, Russia.
I V KokorevStudent, Department of Biotechnology and Industrial Pharmacy; MIREA - Russian Technological University, 78 Vernadsky Avenue, Moscow, 119454, Russia.
I A GrivennikovDSc, Professor, Chief Researcher, Laboratory of Molecular Neurogenetics and Natural Immunity; National Research Center "Kurchatov Institute", 1 Academician Kurchatov Square, Moscow, 123182, Russia.
V S SukhorukovMD, DSc, Professor, Head of Laboratory of Neuromorphology, Institute of Brain Research; Russian Research Center of Neurology and Neurosciences, 80 Volokolamskoye Shosse, Moscow, 125367, Russia; Professor, Department of Morphology, Institute of Anatomy and Morphology; Pirogov Russian National Research Medical University, 1 Bldg., 6 Ostrovityanova St., Moscow, 117513, Russia.
S N IllarioshkinMD, DSc, Professor, Academician of the Russian Academy of Sciences, Director of Institute of Brain Research; Russian Research Center of Neurology and Neurosciences, 80 Volokolamskoye Shosse, Moscow, 125367, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: Monolayer astrocyte cultures differentiated from iPSCs from a healthy donor and a PD patient having the G2019S mutation in the Results: PCR analysis and immunocytochemical staining demonstrated that cell lines received from a healthy donor and a PD patient expressed the required pattern of glia-specific genes and synthesized astrocyte-specific proteins. However, some glia-specific genes were expressed at reduced levels by mutant cells. One of the most typical ultrastructural features of astrocytes received from iPSCs from a PD patient was destructive changes in mitochondria, including mitochondrial clearing, swelling, and cristae destruction. In many cells, mitochondria were completely absent after a long culturing. Another characteristic feature of cells with a mutation in the Conclusion: Reprogramming and obtaining of astrocytes from iPSCs received from a donor with a PD-associated mutation in the

Indexed as

AstrocytesCell DifferentiationInduced Pluripotent Stem CellsParkinson DiseaseHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Microscopy, Electron, TransmissionMitochondriaMutationPhenotypeLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanastrocytesdifferentiationelectron microscopyinduced pluripotent stem cellsLRRK2Parkinson’s disease

Identifiers

PMID41867642
PMCPMC13003593

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.