ArticleFrontiers in nutrition2026
Evaluation of FGL1 as a hepatokine marker in iron deficiency.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Fibrinogen-like protein 1 (FGL1) is a hepatokine that regulates hepcidin through antagonism of the bone morphogenetic protein (BMP) pathway. Although preclinical studies suggest a role for FGL1 in iron metabolism, its clinical behavior in human iron deficiency anemia (IDA) remains unclear. This study evaluates circulating FGL1 levels in IDA and examines its diagnostic performance and relationship with hematologic and biochemical markers. Methods: This cross-sectional study included 112 participants: healthy controls ( Results: Serum FGL1 concentrations were significantly higher in primary IDA (median 411.2 ng/ml) and IDA+CD (median 292.99 ng/ml) than in healthy controls (median 212.49 ng/ml; Conclusion: Fibrinogen-like protein 1 is markedly elevated in iron deficiency and aligns with the broader biochemical signature of iron-restricted erythropoiesis. Its strong ability to distinguish healthy individuals from those with iron deficiency suggests diagnostic potential, particularly when ferritin interpretation is limited.
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