ArticleNeuropsychiatric disease and treatment2026
Threshold Effect of Anxiety in the Comorbidity of Depression and Chronic Pain: A Cross-Sectional Study Based on Pain Sensitivity.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The considerable co-prevalence of major depressive disorders (MDD), anxiety symptoms, and chronic pain (CP) indicates a complex link with significant treatment ramifications. This study elucidates the role of pain sensitivity as a potential etiological factor in anxiety and depression. Methods: This cross-sectional study recruited 124 participants divided into a health control group (HC, n=48), patients with depression without CP group (MDD, n=38) and comorbidity group of patients with MDD and CP (COM, n=38). Clinical assessments included the Hamilton Depression Rating Scale-24 (HAMD-24), Beck Depression Inventory-II (BDI-II), Hamilton Anxiety Rating Scale-14 (HAMA-14), and Beck Anxiety Inventory (BAI) to evaluate depressive and anxiety symptoms. The 36-Item Short Form Health Survey (SF-36) quantified health-related quality of life, while the Pain Sensitivity Questionnaire (PSQ) and Pain Intensity Numerical Rating Scale (PI-NRS) assessed pain sensitivity and pain intensity, respectively. A piecewise regression model identified clinical thresholds. Results: The COM group showed higher BAI ( Conclusion: Our findings reveal that when pain sensitivity exceeds the threshold (PSQ≥4.14), anxiety significantly amplifies pain perception, forming a "pain-anxiety-depression" positive feedback loop. This finding provides an empirical foundation for personalized therapy.
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