Evidence map›Paper›PMID 41867740›Full record

ArticlebioRxiv : the preprint server for biology2026

Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day-Dependent Manner.

Gretchen T Clark, Yue Zhao, Robyn E Reeve, Colleen M Farley, Courtney Willey, Susan Sheehan, Samantha Spellacy, Alicia Warren, Abigail Brackett, Nadia A Rosenthal and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gretchen T ClarkThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-0369-3677
Yue ZhaoThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Robyn E ReeveThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0009-0007-8412-2329
Colleen M FarleyThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-4631-545X
Courtney WilleyThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-4573-9648
Susan SheehanThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-1409-0679
Samantha SpellacyThe Jackson Laboratory, Bar Harbor, ME, USA.
Alicia WarrenThe Jackson Laboratory, Bar Harbor, ME, USA.
Abigail BrackettThe Jackson Laboratory, Bar Harbor, ME, USA.
Nadia A RosenthalThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-7599-7365
Ron KorstanjeThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-2808-1610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The circadian rhythm orchestrates gene expression and critical physiological processes but becomes disrupted with aging, contributing to disease. How this disruption interacts with cellular senescence-a key driver of aging pathology-remains poorly defined. We studied renal gene expression at four timepoints over 24hrs in 6- and 24-month-old genetically diverse UM-HET3 mice of both sexes and performed complementary analyses in synchronized fibroblasts sampled at seven timepoints. Aging dysregulated core clock relationships, including loss of the canonical anti-phase expression between

Indexed as

agingBmal1Cdkn1aCircadian rhythmsenescencesenescence associated secretory phenotypesex differences

Identifiers

PMID41867740
PMCPMC13001320

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.