Evidence map›Paper›PMID 41867749›Full record

ArticlebioRxiv : the preprint server for biology2026

Myofibroblast lineage mapping and inhibiting subretinal fibrosis by targeting SMAD3 and MRTF pathways via microRNA-24 functional study.

Yinga Wu, Yao Tong, Katherine G Byrnes, Qi Zhou, Chunmin Dong, Chase Benjamin, Emma Parker, Duran Bao, Zhaoyang Ren, Chastain A Anderson and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yinga WuDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.ORCID 0000-0003-4422-1131
Yao TongDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Katherine G ByrnesDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Qi ZhouDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Chunmin DongDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Chase BenjaminDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Emma ParkerDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Duran BaoCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA 70112 USA.
Zhaoyang RenDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Chastain A AndersonDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Rafael L Ufret-VincentyDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Yu-Guang HeDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Ze ZhangDepartment of Ophthalmology, Tulane University, New Orleans, LA, 70118, USA.
David HinkleDepartment of Ophthalmology, Tulane University, New Orleans, LA, 70118, USA.
Jing MaDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.
Shusheng WangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA.

Funding

Regulation of Ocular Angiogenesis by microRNAsR01EY021862 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, SHUSHENG · 2011 to 2021
$2.8M
Does age/stress-induced mitochondrial dysfunction induce variations in RPE phenotype in AMD?R01EY035805 · NEI · TULANE UNIVERSITY OF LOUISIANA · PI James T Handa, Shusheng Wang · 2024 to 2026
$1.9M
Role of long noncoding RNAs in human ocular angiogenesisR01EY026069 · NEI · TULANE UNIVERSITY OF LOUISIANA · PI WANG, SHUSHENG · 2016 to 2020
$1.9M
Mechanistic study and therapeutic development for subretinal fibrosisR01EY034571 · NEI · TULANE UNIVERSITY OF LOUISIANA · PI Shusheng Wang · 2023 to 2026
$1.6M
NEI NIH HHS R01 EY021862NEI NIH HHS R01 EY026069NEI NIH HHS R01 EY034571NEI NIH HHS R01 EY035805
6 · The paper itself

Abstract

Subretinal fibrosis underlies the end-stage pathogenesis of retinal diseases including age-related macular degeneration (AMD). It can disrupt retinal structure and eventually lead to legal blindness by generating contractile force, fibrotic scarring, subretinal hemorrhage, and retinal detachment. Myofibroblasts are the predominant cells critically involved in subretinal fibrosis, however, the cellular contribution to myofibroblasts remains unclear. Here we demonstrate that multiple cell lineages, including macrophages, endothelial cells (EC), retinal pigment epithelial (RPE) cells and pericytes, significantly contribute to myofibroblasts in a laser-induced subretinal fibrosis model. We found microRNA

Identifiers

PMID41867749
PMCPMC13001460

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.