Evidence map›Paper›PMID 41867821›Full record

ArticlebioRxiv : the preprint server for biology2026

Cell-type specific impact of opioid use disorder and HIV on the human forebrain and cerebellum.

Abbey A Green, Tanmayi D Vashist, Shweta Jakhmola, Xinze Chen, Gulshanbir Baidwan, Justin Buchanan, Shashi Kant Tiwari, Emily Griffin, Abigail Howell, Yuna Lee and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Abbey A GreenDepartment of Cognitive Science, University of California, San Diego.
Tanmayi D VashistBiomedical Sciences Graduate Program, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Shweta JakhmolaDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Xinze ChenDepartment of Cognitive Science, University of California, San Diego.
Gulshanbir BaidwanDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Justin BuchananDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Shashi Kant TiwariDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Emily GriffinDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Abigail HowellDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Yuna LeeDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
David J MooreDepartment of Psychiatry, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Sara GianellaDepartment of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Davey M SmithDepartment of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Quan ZhuDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Consuelo Walss-BassFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Allen WangDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Eran A MukamelDepartment of Cognitive Science, University of California, San Diego.ORCID 0000-0003-3203-9535
Kyle J GaultonDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.
Tariq M RanaDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093 USA.ORCID 0000-0001-9558-5766

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SONIA JAIN · 1994 to 2026
$78.4M
DATA COORDINATING CENTER TO PROVIDE SERVICES TO WORK COLLABORATIVELY WITH THE NATIONAL NEUROHIV TISSUE CONSORTIUM CLINICAL SITES TO PROVIDE MANAGEMENT AND DATABASE CAPABILITIES, SCIENTIFIC EXPERTISE, 75N95023C00013 · NIDA · THE EMMES COMPANY, LLC · PI SHERMAN, SETH · 2023 to 2025
$11.2M
Revealing the single cell determinants of brain relevant to persistent HIV infection and opioid use disorderU01DA053630 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2021 to 2025
$11.2M
Project-004P01AI169609 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 2022 to 2026
$10.6M
NeMO Archive: SCORCH Support, Coordination and OutreachUM1DA052244 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI Seth Abrams Ament, Anup Mahurkar · 2020 to 2026
$10.2M
THE NNTC COLLECTS, STORE, AND PROVIDE CLINICAL DATA AND WELL CHARACTERIZED BIOLOGICAL SPECIMENS, INCLUDING POST-MORTEM TISSUE FROM STUDY VOLUNTEERS AND/OR ORGAN DONORS WITH HIV AS WELL AS HIV-NEGATIVE75N95023C00015 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HADIJAH, VACTOR · 2023 to 2025
$9.0M
THE NNTC COLLECTS, STORE, AND PROVIDE CLINICAL DATA AND WELL CHARACTERIZED BIOLOGICAL SPECIMENS, INCLUDING POST-MORTEM TISSUE FROM STUDY VOLUNTEERS AND/OR ORGAN DONORS WITH HIV AS WELL AS HIV-NEGATIVE75N95023C00014 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, DAVID J · 2023 to 2025
$6.6M
Investigating the molecular mechanisms of HIV/AIDS associated neurological disorders using microglia and cerebral organoids derived from induced pluripotent stem cellsR01DA049524 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2019 to 2023
$3.9M
THE NIH NATIONAL NEUROHIV TISSUE CONSORTIUM (NNTC) - NEW CLINICAL SITE75N95024C00027 · NIMH · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2024 to 2025
$3.7M
UC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6M
THE NNTC COLLECTS, STORE, AND PROVIDE CLINICAL DATA AND WELL CHARACTERIZED BIOLOGICAL SPECIMENS, INCLUDING POST-MORTEM TISSUE FROM STUDY VOLUNTEERS AND/OR ORGAN DONORS WITH HIV AS WELL AS HIV-NEGATIVE75N95023C00016 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GELMAN, BENJAMIN · 2023 to 2025
$1.9M
THE NNTC COLLECTS, STORE, AND PROVIDE CLINICAL DATA AND WELL CHARACTERIZED BIOLOGICAL SPECIMENS, INCLUDING POST-MORTEM TISSUE FROM STUDY VOLUNTEERS AND/OR ORGAN DONORS WITH HIV AS WELL AS HIV-NEGATIVE75N95023C00017 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIBSON, MARY · 2023 to 2025
$1.4M
NIAID NIH HHS P01 AI169609NIAID NIH HHS P30 AI036214NIDA NIH HHS 75N95023C00013NIDA NIH HHS 75N95023C00016NIDA NIH HHS R01 DA049524NIDA NIH HHS U01 DA053630NIDA NIH HHS UM1 DA052244NIGMS NIH HHS T32 GM145427NIH HHS 75N95023C00014NIH HHS 75N95023C00015NIH HHS 75N95023C00017NIH HHS 75N95024C00027NIH HHS S10 OD026929
6 · The paper itself

Abstract

Opioid use disorder (OUD), which frequently co-occurs with HIV infection, causes long-term neurological disease, yet the epigenetic and transcriptomic effects of OUD and HIV on specific cell types and regions of the brain are poorly understood. To assess the cell-type specific impacts of OUD and HIV across the human brain, we measured single cell transcriptomes and epigenomes of 580,353 cells in the prefrontal cortex, amygdala and cerebellum of 44 donors. We cataloged over 750k candidate

Indexed as

chromatin accessibility (scATAC-seq)dopamine circuitryepigenomics/transcriptomicsgene regulatory networksHIV-associated neurocognitive disorder (HAND)neuroinflammationopioid use disorderreward circuitrysingle-cell multiomics

Identifiers

PMID41867821
PMCPMC13001470

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.