Evidence mapPaperPMID 41867824Full record

ArticlebioRxiv : the preprint server for biology2026

Females are protected from semaglutide-induced muscle loss in

Subhasmita Rout, Takuya Karasawa, Shinya Watanabe, Amandine Chaix, Micah J Drummond, Katsuhiko Funai, Ran Hee Choi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Subhasmita RoutDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Takuya KarasawaDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Shinya WatanabeDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Amandine ChaixDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-7007-197X
Micah J DrummondDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Katsuhiko FunaiDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-3802-4756
Ran Hee ChoiDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.

Funding

Ceramides as novel drivers of metabolic dysfunction and colorectal cancerU01CA272529 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$992k
NCI NIH HHS U01 CA272529
6 · The paper itself

Abstract

Obesity is a major contributor to cardiometabolic disease, and pharmacological therapies such as semaglutide are increasingly used to induce weight loss. However, the commonly used diet-induced obesity model in C57BL/6J mice is limited by relative resistance to weight gain in females, complicating the study of sex-specific effects. Here, we used leptin-deficient

Indexed as

mitochondriamuscle forceobesitysemaglutideskeletal muscleweight loss

Identifiers

PMID41867824
PMCPMC13001401

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.